Sulfur-mediated polycarbonate polyurethane for potential application of blood-contacting materials
Abstract: In this study, a sulfur-mediated polycarbonate polyurethane (PCU-SS) is developed by mimicking the catalyzing ability of glutathione peroxidase (GPx) on nitric oxide (NO) in the human body. The PCU-SS is endowed with the capability to produce NO based on disulfide bonds, which could strongly improve the biocompatibility of the materials. The characterization results indicate that PCU-SS could not only decrease the adhesion of platelets but also enhance the capability of anti-thrombus. Moreover, it is shown that PCU-SS has a good compatibility with endothelial cells (ECs), while has a marked inhibition capacity of the proliferation of smooth muscle cells (SMCs) and macrophages (MA). Meanwhile, the result of animal implantation experiments further demonstrates the good abilities of PCU-SS on anti-inflammation, anti-thrombus, and anti-hyperplasia. Our results offer a novel strategy for the modification of blood-contacting materials based on disulfide bonds. It is expected that the PCU-SS could shed new light on biocompatibility improvement of cardiovascular stents
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Frontiers in bioengineering and biotechnology. - 10 (2022) , 874419, ISSN: 2296-4185
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2022
- Creator
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Li, Peichuang
Cai, Wanhao
Li, Xin
Zhang, Hong
Zhao, Yuancong
Wang, Jin
- DOI
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10.3389/fbioe.2022.874419
- URN
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urn:nbn:de:bsz:25-freidok-2260327
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
Data provider
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Associated
- Li, Peichuang
- Cai, Wanhao
- Li, Xin
- Zhang, Hong
- Zhao, Yuancong
- Wang, Jin
- Universität
Time of origin
- 2022
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