Flavivirus Concentrates Host ER in Main Replication Compartments to Facilitate Replication
Abstract: Flavivirus remodels the host endoplasmic reticulum (ER) to generate replication compartments (RCs) as the fundamental structures to accommodate viral replication. Here, a centralized replication mode of flavivirus is reported, i.e., flavivirus concentrates host ER in perinuclear main replication compartments (MRCs) for efficient replication. Superresolution live‐cell imaging demonstrated that flavivirus MRCs formed via a series of events, including multisite ER clustering, growth and merging of ER clusters, directional movement, and convergence in the perinuclear region. The dynamic activities of viral RCs are driven by nonstructural (NS) proteins and are independent of microtubules and actin. Moreover, disrupting MRCs formation by small molecule compounds inhibited flavivirus replication. Overall, the findings reveal unprecedented insight into dynamic ER reorganization by flavivirus and identify a new inhibition strategy.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Flavivirus Concentrates Host ER in Main Replication Compartments to Facilitate Replication ; day:27 ; month:10 ; year:2023 ; extent:11
Advanced science ; (27.10.2023) (gesamt 11)
- Creator
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Ci, Yali
Han, Kai
Kong, Jie
Huang, Shuhan
Yang, Yang
Qin, Cheng‐Feng
Shi, Lei
- DOI
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10.1002/advs.202305093
- URN
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urn:nbn:de:101:1-2023102715300097040744
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:47 AM CEST
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Associated
- Ci, Yali
- Han, Kai
- Kong, Jie
- Huang, Shuhan
- Yang, Yang
- Qin, Cheng‐Feng
- Shi, Lei
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