SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase

Abstract: Guanine‐quadruplexes (G4) included in RNA molecules exert several functions in controlling gene expression at post‐transcriptional level; however, the molecular mechanisms of G4‐mediated regulation are still poorly understood. Here, we describe a regulatory circuitry operating in the early phases of murine muscle differentiation in which a long non‐coding RNA (SMaRT) base pairs with a G4‐containing mRNA (Mlx‐γ) and represses its translation by counteracting the activity of the DHX36 RNA helicase. The time‐restricted, specific effect of lnc‐SMaRT on the translation of Mlx‐γ isoform modulates the general subcellular localization of total MLX proteins, impacting on their transcriptional output and promoting proper myogenesis and mature myotube formation. Therefore, the circuitry made of lnc‐SMaRT, Mlx‐γ, and DHX36 not only plays an important role in the control of myogenesis but also unravels a molecular mechanism where G4 structures and G4 unwinding activities are regulated in living cells.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase ; volume:21 ; number:6 ; year:2020 ; extent:17 ; EMBO reports / European Molecular Biology Organization ; 21, Heft 6 (2020) (gesamt 17)

Beteiligte, Orts- und Zeitangaben

• Urheber: Martone, Julie ; Mariani, Davide ; Santini, Tiziana ; Setti, Adriano ; Shamloo, Sama ; Colantoni, Alessio ; Capparelli, Francesca ; Paiardini, Alessandro ; Dimartino, Dacia ; Morlando, Mariangela ; Bozzoni, Irene

Weitere Informationen

• DOI: 10.15252/embr.201949942
• URN: urn:nbn:de:101:1-2022062910414417178890
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:38 MESZ