Hepatitis C virus and human cytomegalovirus - natural killer cell subsets in persistent viral infections
Abstract: Hepatitis C virus (HCV) and human cytomegalovirus (HCMV) are prominent examples of RNA and DNA viruses, respectively, that establish a persistent infection in their host. HCV affects over 185 million patients worldwide, who are at high risk for developing liver fibrosis, liver cirrhosis, and ultimately hepatocellular carcinoma. Recent breakthroughs in HCV therapy, using direct-acting antivirals have provided the opportunity to monitor natural killer (NK) cells after clearance of a chronic infection. There is now increasing evidence that the individual NK cell repertoire before infection is predictive for the course of disease. HCMV affects the majority of the global population. While being asymptomatic in healthy individuals, HCMV represents a severe clinical challenge in immunocompromised patients. Both viral infections, HCV and HCMV, lead to long-lasting and profound alterations within the entire NK cell compartment. This review article, will discuss the diverse range of changes in the NK cell compartment as well as potential consequences for the course of disease
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Frontiers in immunology. - 8 (2017) , 566, ISSN: 1664-3224
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2021
- Creator
- DOI
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10.3389/fimmu.2017.00566
- URN
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urn:nbn:de:bsz:25-freidok-2207406
- Rights
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Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:28 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Pollmann, Julia
- Rölle, Alexander
- Hofmann, Maike
- Cerwenka, Adelheid
- Universität
Time of origin
- 2021
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Congenital cytomegalovirus infection after maternal persistent immunoglobulin-M antibodies against cytomegalovirus prior to conception
Blood and alveolar lymphocyte subsets in pulmonary cytomegalovirus infection after lung transplantation
Altered phenotype of natural killer cell subsets after haploidentical stem cell transplantation
Diagnostic stewardship to limit repeat plasma cytomegalovirus viral load testing
Effect of persistent antigen expression on cytomegalovirus-specific T-cell responses
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Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells
Mouse Cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells
Correlation of cytomegalovirus viral load between whole blood and plasma of congenital cytomegalovirus infection under valganciclovir treatment
Role of the cytomegalovirus early 1 protein isoforms during viral replication
The role of the murine cytomegalovirus protein m139 in viral tropism
Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner
Congenital cytomegalovirus infection after maternal persistent immunoglobulin-M antibodies against cytomegalovirus prior to conception
Blood and alveolar lymphocyte subsets in pulmonary cytomegalovirus infection after lung transplantation
Altered phenotype of natural killer cell subsets after haploidentical stem cell transplantation
Diagnostic stewardship to limit repeat plasma cytomegalovirus viral load testing
Effect of persistent antigen expression on cytomegalovirus-specific T-cell responses
Effect of Persistent Antigen Expression on Cytomegalovirus-Specific T Cell Responses
Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells
Mouse Cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells
Correlation of cytomegalovirus viral load between whole blood and plasma of congenital cytomegalovirus infection under valganciclovir treatment
Role of the cytomegalovirus early 1 protein isoforms during viral replication