Monitoring Minimal Residual Disease in RUNX1 -Mutated Acute Myeloid Leukemia
Introduction: Mutated RUNX1 is considered a poor prognostic factor and usually is mutually exclusive with NPM1 mutations. Monitoring of molecular markers for minimal residual disease provides a powerful tool to assess remission and guide clinical decisions. Methods: Newly diagnosed RUNX1-mutated AML patients, designated to intensive chemotherapy-based treatment or nonintensive regimens, were monitored for mutated RUNX1 transcript levels by qPCR with patient-specific primers. Samples were obtained along the treatment course and follow-up. Results: A clear correlation was observed between mutated RUNX1 levels and response to treatment as observed by flow cytometry and STR-based assessment. Conclusion: We demonstrate the feasibility of RUNX1-based MRD to correlate with the clinicopathological status of leukemia. We further suggest how RUNX1 qPCR monitoring can influence clinical decision-making and contribute to improved personalized patient care.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Monitoring Minimal Residual Disease in RUNX1 -Mutated Acute Myeloid Leukemia ; volume:145 ; number:6 ; year:2022 ; pages:642-649 ; extent:8
Acta haematologica ; 145, Heft 6 (2022), 642-649 (gesamt 8)
- Creator
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Nachmias, Boaz
Krichevsky, Svetlana
Filon, Dvora
Even-Or, Ehud
Gatt, Moshe E.
Saban, Revital
Avni, Batia
Grisariu, Sigal
Aumann, Shlomzion
Vainstein, Vladimir
- DOI
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10.1159/000526353
- URN
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urn:nbn:de:101:1-2022120723335088053199
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:38 AM CEST
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Associated
- Nachmias, Boaz
- Krichevsky, Svetlana
- Filon, Dvora
- Even-Or, Ehud
- Gatt, Moshe E.
- Saban, Revital
- Avni, Batia
- Grisariu, Sigal
- Aumann, Shlomzion
- Vainstein, Vladimir
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