Disseminated Intravascular Coagulation score predicts mortality in patients with liver disease and low fibrinogen level.

Background: Alongside its original diagnostic intention, the International Society on Thrombosis and Haemostasis’ Disseminated Intravascular Coagulation (DIC) score predicts mortality in various patient groups. Objectives: We investigated whether coagulopathy quantified by the DIC score can predict 30-day mortality in patients with liver disease and low fibrinogen levels. Methods: We retrospectively analyzed all patients admitted to the Vienna General Hospital between 2003-2014 with a fibrinogen level of <150 mg/dL, a history of liver disease, and ≥2 pathological DIC parameters. We used a Cox regression and Receiver Operating Characteristic analysis to assess the predictive value of the ISTH-DIC score in its original (DIC-2001) and revised form (DIC-2018). Results: 1333 patients were screened, and 388 of these patients (38% female, median age 58 years, IQR 48-66 years) were analyzed. The DIC-2001 (HR 2.08, 95%CI 1.78 - 2.59, p < 0.001) and DIC-2018 (HR 1.73, 95%CI 1.51 – 2.05, p < 0.001) predicted 30-day mortality. The results remained robust in several sensitivity analyses. Conclusions: The ISTH DIC-2001 and DIC-2018 scores predicted 30-day mortality in patients with liver disease and low fibrinogen levels. The DIC score deserves further investigation in this population as it likely reflects different dimensions of the underlying disease.

Object Details

• Alternative title: DIC score in liver patients
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Disseminated Intravascular Coagulation score predicts mortality in patients with liver disease and low fibrinogen level. ; day:16 ; month:08 ; year:2022 ; Thrombosis and haemostasis ; (16.08.2022)

Contributors, Places and Time

• Contributor: Grafeneder, Juergen ; Buchtele, Nina ; Egger, Daniel ; Schwameis, Michael ; Ay, Cihan ; Jilma, Bernd ; Schoergenhofer, Christian

Further information

• DOI: 10.1055/a-1925-2300
• URN: urn:nbn:de:101:1-2022101019320502297488
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:35 AM CEST