The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms with COVID-19 severity : A systematic review and meta-analysis

Abstract: Genes involved in the regulation of viral recognition and its entry into a host cell have been identified as candidates for genetic association studies on COVID-19 severity. Published findings on the effects of polymorphisms within ACE1, ACE2, TMPRSS2, IFITM3 and VDR genes remained inconclusive, so we conducted a systematic review and meta-analysis in order to elucidate their potential involvement in the genetic basis underlying the severity of COVID-19 and/or an outcome of SARS-CoV-2 infection. Identification of potentially eligible studies was based on PubMed, Scopus and Web of Science database search. Relevant studies (n=29) with a total number of 8247 SARS-CoV-2-positive participants were included in qualitative synthesis, while results of 21 studies involving 5939 were pooled in meta-analysis. Minor allele I of rs1799752 located within ACE1 was identified as a protective variant against severe COVID-19, while its effect on mortality rate was opposite. Similarly, minor allele A.... https://www.excli.de/index.php/excli/article/view/4976

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms with COVID-19 severity ; volume:21 ; day:20 ; month:06 ; year:2022 ; EXCLI journal ; 21 (20.06.2022)

Contributors, Places and Time

• Creator: Dobrijević, Zorana ; Robajac, Dragana ; Gligorijević, Nikola ; Šunderić, Miloš ; Penezić, Ana ; Miljuš, Goran ; Nedić, Olgica

Further information

• DOI: 10.17179/excli2022-4976
• URN: urn:nbn:de:101:1-2022070815001669725140
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 07.09.20252025, 7:42 AM CEST