A titanium‐catalyzed reductive [alpha]‐desulfonylation
Abstract: A titanium(III)‐catalyzed desulfonylation gives access to functionalized alkyl nitrile building blocks from α‐sulfonyl nitriles, circumventing traditional base‐mediated α‐alkylation conditions and strong single electron donors. The reaction tolerates numerous functional groups including free alcohols, esters, amides, and it can be applied also to the α‐desulfonylation of ketones. In addition, a one‐pot desulfonylative alkylation is demonstrated. Preliminary mechanistic studies indicate a catalyst‐dependent mechanism involving a homolytic C−S cleavage
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Chemistry – a European journal. - 27, 20 (2021) , 6178-6182, ISSN: 1521-3765
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2021
- Urheber
- DOI
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10.1002/chem.202005400
- URN
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urn:nbn:de:bsz:25-freidok-1944566
- Rechteinformation
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:03 MESZ
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Beteiligte
- Kern, Christoph
- Selau, Jan
- Streuff, Jan
- Universität
Entstanden
- 2021
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