Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
Abstract: Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10−13), 1q42.13 (rs41271473, P=1.06 × 10−10), 4q24 (rs71597109, P=1.37 × 10−10), 4q35.1 (rs57214277, P=3.69 × 10−8), 6p21.31 (rs3800461, P=1.97 × 10−8), 11q23.2 (rs61904987, P=2.64 × 10−11), 18q21.1 (rs1036935, P=3.27 × 10−8), 19p13.3 (rs7254272, P=4.67 × 10−8) and 22q13.33 (rs140522, P=2.70 × 10−9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Nature communications. - 8 (2017) , 8:14175, ISSN: 2041-1723
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2021
- Urheber
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Law, Philip J.
Berndt, Sonja I.
Speedy, Helen E.
Camp, Nicola Jane
Sava, Georgina P.
Skibola, Christine F.
Nieters, Alexandra
Houlston, Richard
Slager, Susan L.
- DOI
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10.1038/ncomms14175
- URN
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urn:nbn:de:bsz:25-freidok-1936200
- Rechteinformation
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:56 MEZ
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Beteiligte
- Law, Philip J.
- Berndt, Sonja I.
- Speedy, Helen E.
- Camp, Nicola Jane
- Sava, Georgina P.
- Skibola, Christine F.
- Nieters, Alexandra
- Houlston, Richard
- Slager, Susan L.
- Universität
Entstanden
- 2021
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