Degradable poly(styrene sulfonate) polyanions for biomedical and electrochemical applications

Abstract: The synthesis of poly(styrene sulfonate) with hydrolysable ester groups in the main chain is reported. The material is obtained by free radical copolymerization of either styrene sulfonate sodium salt (SSNa) or styrene sulfonate alkyl esters (SSA) with the cyclic ketene acetal 2-methylen-1,3,6-trioxocane (MTC). As for other systems made from cyclic ketene acetals, the reactions are difficult to control and give copolymers with high polydispersity index. MTC homopolymer is obtained as a side product in both cases. Thermal cleavage of the alkyl protective groups of the poly(styrene sulfonate alkyl esters) to obtain the target polystyrene sulfonate anions remains incomplete. Thus, direct synthesis of the polyanion from SSNa and MTC is the more efficient process, especially since the poly(SSNa-co-MTC) copolymer can be easily separated from MTC homopolymer. 1H-NMR analytics indicates MTC repeat unit contents of 2–11%, depending on the initial SSNa to MTC ratio. The MTC ester groups of the copolymers are hydrolyzed in aqueous conditions, with and without enzyme, and a marked decrease in the molar mass is observed after hydrolysis. This confirms that these copolymers have the designed intended break points in the main chain, and could become a part of fully degradable electroactive polymer systems

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• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Macromolecular chemistry and physics. - 224, 23 (2023) , 2300219, ISSN: 1521-3935

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2024
• Creator: Zober, Maria ; Helchenbichler, Michelle ; Bleiziffer, Alexander ; Prediger, Richard ; Lienkamp, Karen

Further information

• DOI: 10.1002/macp.202300219
• URN: urn:nbn:de:bsz:25-freidok-2543765
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.