Autoimmune Liver Disease in Human Immunodeficiency Virus-Infected Patients: 3 Case Series

We present 3 cases of autoimmune liver disease in human immunodeficiency virus (HIV)-infected patients and describe the different diagnostic and therapeutic approaches used in each case. The first patient was diagnosed with primary biliary cholangitis (PBC) with features of autoimmune hepatitis (AIH), requiring second-line therapy due to incomplete response to ursodeoxycholic acid. The second patient was diagnosed with AIH with features of PBC and had the particular challenges of presenting with advanced liver fibrosis and having a past history of disseminated cytomegalovirus infection. The last case concerns an AIH with acute liver injury, successfully treated with corticosteroids and azathioprine. Recently, the number of patients on antiretroviral therapy (ART) for HIV disease has increased significantly. Therefore, more patients with this chronic infection have been diagnosed with autoimmune diseases, leading to concerns regarding immunosuppressive therapies in this population. With these cases, we alert for these increasingly incident diseases and support the safety of immunosuppressive therapies, provided that HIV is suppressed with ART.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Autoimmune Liver Disease in Human Immunodeficiency Virus-Infected Patients: 3 Case Series ; volume:30 ; number:Suppl 2 ; year:2022 ; pages:26-31 ; extent:6 ; Portuguese journal of gastroenterology ; 30, Heft Suppl 2 (2022), 26-31 (gesamt 6)

Contributors, Places and Time

• Creator: Rafael, Maria Ana ; Bordalo Ferreira, Filipa ; Theias Manso, Rita ; Peruzzu, Francesca ; Cardoso, Mariana

Further information

• DOI: 10.1159/000527337
• URN: urn:nbn:de:101:1-2023111523290722698234
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:29 AM CEST