Arbeitspapier
Optimal designs for dose-response models with restricted design spaces
In dose response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We present restricted and unrestricted interval locally optimal designs with respect to a very general class of optimality criteria for estimating the underlying dose response curve. The underlying curve belongs to a diversified set of link functions suitable for the dose response studies and having a common canonical form. These include the fundamental binary response models – the logit and the probit as well as the skewed versions of these models. The results are illustrated through the re-design of a dose ranging trial conducted at the Merck Research Laboratories (Zeng and Zhu, 1997). This work is a generalization of the results of Dai and Zhu (2002) in terms of the design interval, the underlying dose response curve and the optimality criterion.
- Sprache
-
Englisch
- Erschienen in
-
Series: Technical Report ; No. 2004,40
- Thema
-
Binary response model
Dose ranging
Dose response
Link function
General Equivalence Theorem
Locally compound optimal design
Theorie
- Ereignis
-
Geistige Schöpfung
- (wer)
-
Dette, Holger
Biedermann, Stefanie
Zhu, Wei
- Ereignis
-
Veröffentlichung
- (wer)
-
Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
- (wo)
-
Dortmund
- (wann)
-
2004
- Handle
- Letzte Aktualisierung
-
10.03.2025, 11:41 MEZ
Datenpartner
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Objekttyp
- Arbeitspapier
Beteiligte
- Dette, Holger
- Biedermann, Stefanie
- Zhu, Wei
- Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
Entstanden
- 2004
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