T‐cell subsets in allergy and tolerance induction
Abstract: Antigen‐specific T lymphocytes are the central regulators of tolerance versus immune pathology against otherwise innocuous antigens and key targets of antigen‐specific immune therapy. Recent advances in the understanding of T cells in tolerance and allergy resulted from improved technologies to directly characterize allergen‐specific T cells by multiparameter flow cytometry or single‐cell sequencing. This unravelled phenotypically and functionally distinct populations, such as Type 2a T helper cells (Th2a), follicular Th cells (Tfh), regulatory T cells (Treg), Type 1 regulatory T cells (Tr1), and follicular T regulatory cells. Here we will discuss the role of the different Th‐cell subsets in the healthy state, during sensitization and development of allergy, and in tolerance induction by allergen immunotherapy (AIT). To date, the mechanisms of AIT as the only causal treatment of allergy are not completely understood. The analyses of allergen‐specific T cells directly ex vivo during AIT support the concept of specific‐Th2 (a) cell deletion rather than an expansion of allergen‐specific Tr1 or Treg cells as underlying mechanism.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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T‐cell subsets in allergy and tolerance induction ; day:02 ; month:08 ; year:2023 ; extent:6
European journal of immunology ; (02.08.2023) (gesamt 6)
- Creator
- DOI
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10.1002/eji.202249983
- URN
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urn:nbn:de:101:1-2023080215181943730109
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:54 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Suhrkamp, Ina
- Scheffold, Alexander
- Heine, Arndt Guido
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