Beyond the bioorthogonal inverse electron demand Diels-Alder reactions of tetrazines: 2-pyrone-functionalized fluorogenic probes
The applicability of pyrones as bioorthogonal platform was explored in inverse electron demand Diels-Alder reactions with a strained cyclooctyne. Studies showed that the pyrones are indeed suitable for IEDDA reactions under physiological conditions. Furthermore, the stable pyrone moiety could be utilized to construct easily accessible fluorogenic probes. Mutual orthogonality of the IEDDA reaction of 2-pyrones with SPAAC reactions of azides was also explored.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Beyond the bioorthogonal inverse electron demand Diels-Alder reactions of tetrazines: 2-pyrone-functionalized fluorogenic probes ; day:04 ; month:02 ; year:2022
Synthesis ; (04.02.2022)
- Contributor
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Cserép, Gergely B.
Németh, Krisztina
Szatmári, Ágnes
Horváth, Flóra
Imre, Tímea
Kele, Péter
- DOI
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10.1055/a-1761-4672
- URN
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urn:nbn:de:101:1-2022032413072606704327
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:21 AM CEST
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Cserép, Gergely B.
- Németh, Krisztina
- Szatmári, Ágnes
- Horváth, Flóra
- Imre, Tímea
- Kele, Péter
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