Arbeitspapier
Compound Optimal Designs for Percentile Estimation in Dose-Response Models with Restricted Design Intervals
In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy, particularly when human subjects are involved. We present locally optimal designs for the estimation of several percentiles simultaneously on restricted as well as unrestricted design intervals. Our results are applicable to most of the commonly applied link functions with respect to the model under consideration. This work is a generalization of Dai (2000) where he showed that the same results hold for the logit model using Elfving?s approach on trace optimal design (Elfving, 1952).
- Sprache
-
Englisch
- Erschienen in
-
Series: Technical Report ; No. 2005,02
- Thema
-
Dose-response model
link function
percentile estimation
compound optimal design
A-optimality
- Ereignis
-
Geistige Schöpfung
- (wer)
-
Dette, Holger
Biedermann, Stefanie
Zhu, Wei
- Ereignis
-
Veröffentlichung
- (wer)
-
Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
- (wo)
-
Dortmund
- (wann)
-
2005
- Handle
- Letzte Aktualisierung
-
10.03.2025, 11:45 MEZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
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ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften - Leibniz-Informationszentrum Wirtschaft. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Objekttyp
- Arbeitspapier
Beteiligte
- Dette, Holger
- Biedermann, Stefanie
- Zhu, Wei
- Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
Entstanden
- 2005
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