Reaction Optimization of a Suzuki‐Miyaura Cross‐Coupling using Design of Experiments

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Abstract: The combination of lab automation and design of experiments for the execution of screening experiments increases productivity and reduces error‐prone manual work. A self‐developed software tool allows for creating fractional‐factorial experimental design (FFED). Application of FFED on the screening of a Suzuki‐Miyaura cross‐coupling leads to a 93 % reduced design compared to full‐factorial design. The resulting regression model qualitatively shows the positive effect of educt concentrations, time, and temperature and reveals the decrease in conversion at high base concentrations.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Reaction Optimization of a Suzuki‐Miyaura Cross‐Coupling using Design of Experiments ; day:11 ; month:03 ; year:2022 ; extent:7
Chemie - Ingenieur - Technik ; (11.03.2022) (gesamt 7)

Creator: Bobers, Jens
Hahn, Lisa Katharina
Averbeck, Tobias
Brunschweiger, Andreas
Kockmann, Norbert

DOI: 10.1002/cite.202100194

URN: urn:nbn:de:101:1-2022031214032365450255

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:36 AM CEST

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Associated

Bobers, Jens
Hahn, Lisa Katharina
Averbeck, Tobias
Brunschweiger, Andreas
Kockmann, Norbert

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