A case of successful pembrolizumab monotherapy in a patient with advanced lung adenocarcinoma: Use of multiple biomarkers in combination for clinical practice

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Abstract: Clinical treatment is challenging for elderly patients with lung cancer who cannot tolerate chemotherapy, do not have cancer driver genes, and have low expression of PD-L1. Since these patients are usually excluded from clinical studies, evidence-based medicine supporting the use of immunotherapy is lacking. Considering the potentially limited clinical benefits and high associated risk of hyperprogressive disease, determining an appropriate treatment is an urgent clinical challenge. We report a 71 year-old male patient diagnosed with advanced lung adenocarcinoma lacking key driving genes (EGFR, ALK, and ROS-1), and low expression of PD-L1 on tumor cells (10–15%). The tumor tissue showed a low level of microsatellite instability, low tumor mutational burden, and no DNA mismatch repair deficiency on whole-exome sequencing (WES). However, a high blood tumor mutational burden was detected. After considering the biomarkers of therapeutic effect and ruling out the risk of hyperprogressive disease, pembrolizumab 200 mg was administered every 3 weeks for a year (17 cycles). The disease remained stable for >39 months, and adverse effects were mild and well-tolerated. Therefore, a comprehensive biomarker evaluation, especially in elderly patients lacking driving genes, is essential. Liquid biopsy technology and WES may be useful for overcoming the limitations of tissue biopsy.

Standort: Deutsche Nationalbibliothek Frankfurt am Main

Umfang: Online-Ressource

Sprache: Englisch

Erschienen in: A case of successful pembrolizumab monotherapy in a patient with advanced lung adenocarcinoma: Use of multiple biomarkers in combination for clinical practice ; volume:17 ; number:1 ; year:2021 ; pages:53-60 ; extent:8
Open medicine ; 17, Heft 1 (2021), 53-60 (gesamt 8)

Urheber: Guo, Hanfei
Qian, Lei
Chen, Xiao
Zhao, Yuguang
Song, Wei
Guan, Yanjie
Cui, Jiuwei

DOI: 10.1515/med-2021-0404

URN: urn:nbn:de:101:1-2022071515432625190301

Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Letzte Aktualisierung: 15.08.2025, 07:34 MESZ

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Beteiligte

Guo, Hanfei
Qian, Lei
Chen, Xiao
Zhao, Yuguang
Song, Wei
Guan, Yanjie
Cui, Jiuwei

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A case of successful pembrolizumab monotherapy in a patient with advanced lung adenocarcinoma: Use of multiple biomarkers in combination for clinical practice

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A case of successful pembrolizumab monotherapy in a patient with advanced lung adenocarcinoma: Use of multiple biomarkers in combination for clinical practice

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Structure constants from modularity in warped CFT

Strings on warped AdS3 via T J ¯ $$ \mathrmT}\overline{\mathrm{J}} $$ deformations

Heating up holography for single-trace J T ¯ $$ J\overlineT} $$ deformations

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Correlation functions of warped CFT

TsT, black holes, and T T ¯ $$ T\overlineT} $$ + J T ¯ $$ J\overlineT} $$ + T J ¯ $$ T\overlineJ} $$

Bootstrapping holographic warped CFTs or: how I learned to stop worrying and tolerate negative norms

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