Asymmetric Synthesis of Spiropyrazolones by Sequential Organo‐ and Silver Catalysis

to related objects

Abstract: A stereoselective one‐pot synthesis of spiropyrazolones through an organocatalytic asymmetric Michael addition and a formal Conia‐ene reaction has been developed. Depending on the nitroalkene, the 5‐exo‐dig‐cyclization could be achieved by silver‐catalyzed alkyne activation or by oxidation of the intermediate enolate. The mechanistic pathways have been investigated using computational chemistry and mechanistic experiments.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Asymmetric Synthesis of Spiropyrazolones by Sequential Organo‐ and Silver Catalysis ; volume:128 ; number:5 ; year:2016 ; pages:1829-1832 ; extent:4
Angewandte Chemie ; 128, Heft 5 (2016), 1829-1832 (gesamt 4)

Creator: Hack, Daniel
Dürr, Alexander B.
Deckers, Kristina
Chauhan, Pankaj
Seling, Nico
Rübenach, Lukas
Mertens, Lucas
Raabe, Gerhard
Schönebeck, Franziska
Enders, Dieter

DOI: 10.1002/ange.201510602

URN: urn:nbn:de:101:1-2022101008352845969366

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:28 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Hack, Daniel
Dürr, Alexander B.
Deckers, Kristina
Chauhan, Pankaj
Seling, Nico
Rübenach, Lukas
Mertens, Lucas
Raabe, Gerhard
Schönebeck, Franziska
Enders, Dieter

Other Objects (12)

Combined experimental and computational studies of ligand-based selectivities in Pd- and Ni-catalysis

Exploring the reactivity of oxidation state +1 in Palladium and Nickel catalysis : A combined computational and experimental approach

$Exploration of dinuclear Pd(I) catalysis & synthetic developments with $(Me_4}N)SCF_{3}$ as a bench stable and versatile reagent to access high value compounds$

Exploration of dinuclear Pd(I) catalysis & synthetic developments with $(Me_4}N)SCF_{3}$ as a bench stable and versatile reagent to access high value compounds

Reactivity and selectivity in homogeneous nickel catalysis and in the formal conia-ene reaction : a computational and experimental approach

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo‐ and Silver Catalysis

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

Aufsatzsammlung

Domino C-H functionalization/cascade catalysis

Hochschulschrift

Enantioselektive C-C-Verknüpfungen über metallierte chirale Hydrazone

Hochschulschrift

Das Verhalten von Serumlipiden und Serumfettsäuren bei verschiedenen Graden der Koronarsklerose

Asymmetric synthesis with chemical and biological methods

Asymmetric Synthesis of Functionalized Dihydro- and Tetrahydropyrans via an Organocatalytic Domino Michael–Hemiacetalization Reaction

Combined experimental and computational studies of ligand-based selectivities in Pd- and Ni-catalysis

Exploring the reactivity of oxidation state +1 in Palladium and Nickel catalysis : A combined computational and experimental approach

$Exploration of dinuclear Pd(I) catalysis & synthetic developments with $(Me_4}N)SCF_{3}$ as a bench stable and versatile reagent to access high value compounds$

Exploration of dinuclear Pd(I) catalysis & synthetic developments with $(Me_4}N)SCF_{3}$ as a bench stable and versatile reagent to access high value compounds

Reactivity and selectivity in homogeneous nickel catalysis and in the formal conia-ene reaction : a computational and experimental approach

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo‐ and Silver Catalysis

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

Aufsatzsammlung

Domino C-H functionalization/cascade catalysis

Hochschulschrift

Enantioselektive C-C-Verknüpfungen über metallierte chirale Hydrazone

Hochschulschrift

Das Verhalten von Serumlipiden und Serumfettsäuren bei verschiedenen Graden der Koronarsklerose

Asymmetric synthesis with chemical and biological methods

Asymmetric Synthesis of Functionalized Dihydro- and Tetrahydropyrans via an Organocatalytic Domino Michael–Hemiacetalization Reaction

Combined experimental and computational studies of ligand-based selectivities in Pd- and Ni-catalysis

Exploring the reactivity of oxidation state +1 in Palladium and Nickel catalysis : A combined computational and experimental approach

$Exploration of dinuclear Pd(I) catalysis & synthetic developments with $(Me_4}N)SCF_{3}$ as a bench stable and versatile reagent to access high value compounds$

Exploration of dinuclear Pd(I) catalysis & synthetic developments with $(Me_4}N)SCF_{3}$ as a bench stable and versatile reagent to access high value compounds

Reactivity and selectivity in homogeneous nickel catalysis and in the formal conia-ene reaction : a computational and experimental approach

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo‐ and Silver Catalysis

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

Aufsatzsammlung

Domino C-H functionalization/cascade catalysis

Hochschulschrift

Enantioselektive C-C-Verknüpfungen über metallierte chirale Hydrazone

Hochschulschrift

Das Verhalten von Serumlipiden und Serumfettsäuren bei verschiedenen Graden der Koronarsklerose

Asymmetric synthesis with chemical and biological methods

Asymmetric Synthesis of Functionalized Dihydro- and Tetrahydropyrans via an Organocatalytic Domino Michael–Hemiacetalization Reaction

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo‐ and Silver Catalysis

Object Details

References and Relationships

Contributors, Places and Time

Further information

Data provider

Associated

Other Objects (12)

Combined experimental and computational studies of ligand-based selectivities in Pd- and Ni-catalysis

Exploring the reactivity of oxidation state +1 in Palladium and Nickel catalysis : A combined computational and experimental approach

Exploration of dinuclear Pd(I) catalysis & synthetic developments with $(Me_4}N)SCF_{3}$ as a bench stable and versatile reagent to access high value compounds

Reactivity and selectivity in homogeneous nickel catalysis and in the formal conia-ene reaction : a computational and experimental approach

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo‐ and Silver Catalysis

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

Domino C-H functionalization/cascade catalysis

Enantioselektive C-C-Verknüpfungen über metallierte chirale Hydrazone

Das Verhalten von Serumlipiden und Serumfettsäuren bei verschiedenen Graden der Koronarsklerose

Asymmetric synthesis with chemical and biological methods

Asymmetric Synthesis of Functionalized Dihydro- and Tetrahydropyrans via an Organocatalytic Domino Michael–Hemiacetalization Reaction

Combined experimental and computational studies of ligand-based selectivities in Pd- and Ni-catalysis

Exploring the reactivity of oxidation state +1 in Palladium and Nickel catalysis : A combined computational and experimental approach

Exploration of dinuclear Pd(I) catalysis & synthetic developments with $(Me_4}N)SCF_{3}$ as a bench stable and versatile reagent to access high value compounds

Reactivity and selectivity in homogeneous nickel catalysis and in the formal conia-ene reaction : a computational and experimental approach

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo‐ and Silver Catalysis

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

Domino C-H functionalization/cascade catalysis

Enantioselektive C-C-Verknüpfungen über metallierte chirale Hydrazone

Das Verhalten von Serumlipiden und Serumfettsäuren bei verschiedenen Graden der Koronarsklerose

Asymmetric synthesis with chemical and biological methods

Asymmetric Synthesis of Functionalized Dihydro- and Tetrahydropyrans via an Organocatalytic Domino Michael–Hemiacetalization Reaction

Combined experimental and computational studies of ligand-based selectivities in Pd- and Ni-catalysis

Exploring the reactivity of oxidation state +1 in Palladium and Nickel catalysis : A combined computational and experimental approach

Exploration of dinuclear Pd(I) catalysis & synthetic developments with $(Me_4}N)SCF_{3}$ as a bench stable and versatile reagent to access high value compounds

Reactivity and selectivity in homogeneous nickel catalysis and in the formal conia-ene reaction : a computational and experimental approach

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo‐ and Silver Catalysis

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

Domino C-H functionalization/cascade catalysis

Enantioselektive C-C-Verknüpfungen über metallierte chirale Hydrazone

Das Verhalten von Serumlipiden und Serumfettsäuren bei verschiedenen Graden der Koronarsklerose

Asymmetric synthesis with chemical and biological methods

Asymmetric Synthesis of Functionalized Dihydro- and Tetrahydropyrans via an Organocatalytic Domino Michael–Hemiacetalization Reaction

Related objects

Reset password