Metastatic BRAF V600E-Mutated Thyroid Carcinoma: Molecular/Genetic Profiling Brings a New Therapeutic Option

We describe a case of a 46-year-old woman diagnosed with localized PTC 20 years ago, having already undergone several treatments with iodine-131 and then treatment with lenvatinib for metastatic disease, to which she developed intolerance. In 2020, in addition to pleural, thoracic, and abdominal lymph node metastasis, progression with symptomatic vertebral bone metastasis was detected, which led to the equation of new therapeutic options. In this context, a genetic/molecular test was carried out, which identified the BRAF V600E mutation and enabled the start of treatment with dabrafenib/trametinib since June 2020. This treatment allowed functional gain, symptomatic relief, and stabilization of the disease. It demonstrates how, in rare tumors, the personalized medicine approach can bring new treatment possibilities.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Metastatic BRAF V600E-Mutated Thyroid Carcinoma: Molecular/Genetic Profiling Brings a New Therapeutic Option ; volume:15 ; number:3 ; year:2022 ; pages:960-966 ; extent:7 ; Case reports in oncology ; 15, Heft 3 (2022), 960-966 (gesamt 7)

Beteiligte, Orts- und Zeitangaben

• Urheber: Reis, Joana S. ; Costa, Inês ; Costa, Mariana ; Valente, Ana Carmo ; Freitas, Marta Baptista ; Almeida, Catarina Lopes ; Gonçalves, Marina ; Teixeira, Carina ; Ribeiro, Maria ; Caeiro, Cláudia ; Fernandes, Catarina ; Barbosa, Miguel

Weitere Informationen

• DOI: 10.1159/000526533
• URN: urn:nbn:de:101:1-2023010423162840098092
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:30 MESZ