Synthesis and biological evaluation of 4-(2′,4′-difluorobiphenyl-4-yl)-6-arylpyrimidin- 2-amine derivatives
Abstract: 4-(2′,4′-Difluorobiphenyl-4-yl)-6-arylpyrimidin-2-amines 5a–g were synthesized and evaluated for their ability to inhibit various bacterial and fungal strains. The cytotoxicity of the compounds was investigated by a 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay against the Hep-2 cell line. Molecular docking studies were also conducted to locate the binding interaction with the target protein 4LRH.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Synthesis and biological evaluation of 4-(2′,4′-difluorobiphenyl-4-yl)-6-arylpyrimidin- 2-amine derivatives ; volume:22 ; number:6 ; year:2016 ; pages:351-356 ; extent:6
Heterocyclic communications ; 22, Heft 6 (2016), 351-356 (gesamt 6)
- Urheber
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Fathimunnisa, M.
Manikandan, Haridoss
Neelakandan, K.
Rajendra Prasad, N.
Ganesan, M.
- DOI
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10.1515/hc-2016-0050
- URN
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urn:nbn:de:101:1-2501130557355.907183165721
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:28 MESZ
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Beteiligte
- Fathimunnisa, M.
- Manikandan, Haridoss
- Neelakandan, K.
- Rajendra Prasad, N.
- Ganesan, M.
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