Nanocarriers with Multiple Cargo Load—A Comprehensive Preparation Guideline Using Orthogonal Strategies
Abstract: Multifunctional nanocarriers enhance the treatment efficacy for modern therapeutics and have gained increasing importance in biomedical research. Codelivery of multiple bioactive molecules enables synergistic therapies. Coencapsulation of cargo molecules into one nanocarrier system is challenging due to different physicochemical properties of the cargo molecules. Additionally, coencapsulation of multiple molecules simultaneously shall proceed with high control and efficiency. Orthogonal approaches for the preparation of nanocarriers are essential to encapsulate sensitive bioactive molecules while preserving their bioactivity. Preparation of nanocarriers by physical processes (i.e., self‐assembly or coacervation) and chemical reactions (i.e., click reactions, polymerizations, etc.) are considered as orthogonal methods to most cargo molecules. This review shall act as a guideline to allow the reader to select a suitable preparation protocol for a desired nanocarrier system. This article helps to select for combinations of cargo molecules (hydrophilic‐hydrophobic, small‐macro, organic–inorganic) with nanocarrier material and synthesis protocols. The focus of this article lies on the coencapsulation of multiple cargo molecules into biocompatible and biodegradable nanocarriers prepared by orthogonal strategies. With this toolbox, the selection of a preparation method for a known set of cargo molecules to prepare the desired biodegradable and loaded nanocarrier shall be provided.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Nanocarriers with Multiple Cargo Load—A Comprehensive Preparation Guideline Using Orthogonal Strategies ; day:26 ; month:09 ; year:2022 ; extent:18
Macromolecular rapid communications ; (26.09.2022) (gesamt 18)
- Urheber
- DOI
-
10.1002/marc.202200611
- URN
-
urn:nbn:de:101:1-2022092615141424573242
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:29 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Hueppe, Natkritta
- Wurm, Frederik R.
- Landfester, Katharina
Ähnliche Objekte (12)
Developing bio-orthogonal chemistries to prepare nanocarriers for controlled release
The Air Cargo Load Planning Problem
Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery
Artificial Internalizing Receptors: Intracellular Delivery of Cargo Through Bio‐Orthogonal Recognition
Biocompatible nanocarriers
Linguistic evidence for Kuṣāṇa trade routes : Bactrian *λιρτο ‘load, cargo’ and Sanskrit lardayati ‘to load’
Radiolabeled Nanocarriers as Theranostics—Advancement from Peptides to Nanocarriers
Radiolabeled Nanocarriers as Theranostics—Advancement from Peptides to Nanocarriers
Multifunctional pharmaceutical nanocarriers
Precise aminoethylene-based nanocarriers for dynamic nucleic acid delivery: A balancing act between polyplex stability and cargo release
Analyzing drug load and release from pharmaceutical nanocarriers for the treatment of inflammatory bowel diseases
cargo
Developing bio-orthogonal chemistries to prepare nanocarriers for controlled release
The Air Cargo Load Planning Problem
Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery
Artificial Internalizing Receptors: Intracellular Delivery of Cargo Through Bio‐Orthogonal Recognition
Biocompatible nanocarriers
Linguistic evidence for Kuṣāṇa trade routes : Bactrian *λιρτο ‘load, cargo’ and Sanskrit lardayati ‘to load’
Radiolabeled Nanocarriers as Theranostics—Advancement from Peptides to Nanocarriers
Radiolabeled Nanocarriers as Theranostics—Advancement from Peptides to Nanocarriers
Multifunctional pharmaceutical nanocarriers
Precise aminoethylene-based nanocarriers for dynamic nucleic acid delivery: A balancing act between polyplex stability and cargo release
Analyzing drug load and release from pharmaceutical nanocarriers for the treatment of inflammatory bowel diseases
cargo
Developing bio-orthogonal chemistries to prepare nanocarriers for controlled release
The Air Cargo Load Planning Problem
Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery
Artificial Internalizing Receptors: Intracellular Delivery of Cargo Through Bio‐Orthogonal Recognition
Biocompatible nanocarriers
Linguistic evidence for Kuṣāṇa trade routes : Bactrian *λιρτο ‘load, cargo’ and Sanskrit lardayati ‘to load’
Radiolabeled Nanocarriers as Theranostics—Advancement from Peptides to Nanocarriers
Radiolabeled Nanocarriers as Theranostics—Advancement from Peptides to Nanocarriers
Multifunctional pharmaceutical nanocarriers
Precise aminoethylene-based nanocarriers for dynamic nucleic acid delivery: A balancing act between polyplex stability and cargo release
Analyzing drug load and release from pharmaceutical nanocarriers for the treatment of inflammatory bowel diseases