Daidzein‐Based Amphiphilic Small Molecular Antimicrobial Peptidomimetics as Novel Antimicrobial Agents with Anti‐Biofilm Activity
Abstract: A new series of daidzein‐based short peptidomimetic compounds were developed. In this study, we incorporated an alkyl chain with different chain lengths as hydrophobic groups, various amino acids and their respective guanidinium salts as hydrophilic groups. The most potent compound 9 a showed excellent antibacterial activity with minimum inhibitory concentration (MIC) of 8 μM against S. aureus and 32 μM against Escherichia coli. Furthermore, 9 a inhibited more than 65 % S. aureus biofilm formation at sub‐MIC, it also disrupted 69 % pre‐established S. aureus at 64 μM. The cytoplasmic membrane permeability study of 9 a revealed that the depolarization of membrane could be the possible mechanism of action. However, 9 a exhibited moderate toxicity against human erythrocytes.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Daidzein‐Based Amphiphilic Small Molecular Antimicrobial Peptidomimetics as Novel Antimicrobial Agents with Anti‐Biofilm Activity ; volume:9 ; number:22 ; year:2024 ; extent:11
ChemistrySelect ; 9, Heft 22 (2024) (gesamt 11)
- Urheber
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Hong, Zijian
Yu, Tsz Tin
Yasir, Muhammad
Sara, Manjulatha
Black, David StC
Willcox, Mark DP
Kuppusamy, Rajesh
Kumar, Naresh
- DOI
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10.1002/slct.202400502
- URN
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urn:nbn:de:101:1-2406071414472.214373408774
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:48 MESZ
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Beteiligte
- Hong, Zijian
- Yu, Tsz Tin
- Yasir, Muhammad
- Sara, Manjulatha
- Black, David StC
- Willcox, Mark DP
- Kuppusamy, Rajesh
- Kumar, Naresh
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