Regiodivergent C−H and Decarboxylative C−C Alkylation by Ruthenium Catalysis: ortho versus meta Position‐Selectivity
Abstract: Ruthenium (II) biscarboxylate complexes enabled the selective alkylation of C−H and C−C bonds at the ortho‐ or meta‐position. ortho‐C−H Alkylations were achieved with 4‐, 5‐ as well as 6‐membered halocycloalkanes. Furthermore, the judicious choice of the directing group allowed for a full control of ortho‐/meta‐selectivities. Detailed mechanistic studies by experiment and computation were performed and provided strong support for an oxidative addition/reductive elimination process for ortho‐alkylations, while a homolytic C−X cleavage was operative for the meta‐selective transformations.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Regiodivergent C−H and Decarboxylative C−C Alkylation by Ruthenium Catalysis: ortho versus meta Position‐Selectivity ; volume:59 ; number:42 ; year:2020 ; pages:18795-18803 ; extent:9
Angewandte Chemie / International edition. International edition ; 59, Heft 42 (2020), 18795-18803 (gesamt 9)
- Urheber
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Korvorapun, Korkit
Moselage, Marc
Struwe, Julia
Rogge, Torben
Messinis, Antonis M.
Ackermann, Lutz
- DOI
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10.1002/anie.202007144
- URN
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urn:nbn:de:101:1-2022062212242144416367
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:37 MESZ
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Beteiligte
- Korvorapun, Korkit
- Moselage, Marc
- Struwe, Julia
- Rogge, Torben
- Messinis, Antonis M.
- Ackermann, Lutz
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