The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
Abstract: The role of hepatic venous pressure gradient (HVPG) measurement in risk stratification before liver resection is an ongoing area of debate. This study examines the impact of preoperative HVPG levels on overall survival (OS)/time to recurrence (TTR) and postoperative complications after hepatic resection of hepatocellular carcinoma (HCC). Thirty-eight HCC patients undergoing HVPG measurement before liver resection at Cambridge University Hospitals NHS Foundation Trust between January 2014 and April 2022 were retrospectively analysed. Statistical analysis comprised univariable/multivariable Cox/logistic regression to identify risk factors of reduced OS/TTR or 90-day post-resection complications and Kaplan–Meier estimator, log-rank, chi-squared, Fisher's exact, and Mann–Whitney U test, or Student's t-test for survival/subgroup analysis. The median HPVG was 6 (range: 0–14) mmHg. The HVPG was an independent risk factor for poorer TTR in the overall cohort (cut-off: ≥7.5 mmHg (17.18/43.81 months; P = 0.009)). In the subgroup analysis of cirrhotic patients (N = 29 (76%)), HVPG was additionally an independent risk factor for lower OS (cut-off: ≥8.5 mmHg [44.39/76.84 months; P = 0.012]). The HVPG had no impact on OS/TTR in non-cirrhotic patients (N = 9 (24%)), nor was it associated with postoperative complications in any cohort. In conclusion, preoperative HVPG levels are useful predictors for TTR and OS in cirrhotic HCC patients undergoing hepatic resection.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis ; volume:19 ; number:1 ; year:2024 ; extent:13
Open medicine ; 19, Heft 1 (2024) (gesamt 13)
- Creator
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Busch, Felix
De Paepe, Katja N.
Gibbs, Paul
Allison, Michael
Hoare, Matthew
See, Teik Choon
- DOI
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10.1515/med-2023-0851
- URN
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urn:nbn:de:101:1-2024030914371305896412
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:46 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Busch, Felix
- De Paepe, Katja N.
- Gibbs, Paul
- Allison, Michael
- Hoare, Matthew
- See, Teik Choon
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Prognostic role of the hepatic venous pressure gradient in cirrhosis : [kumulative Habilitation]
Impact of catheter tip to hepatic vein ostium distance on the validity and prognostication of hepatic venous pressure gradient in cirrhosis
Impact of propofol sedation on the diagnostic accuracy of hepatic venous pressure gradient measurements in patients with cirrhosis
Hepatic caudate lobe resection
Glucose Intolerance in Liver Cirrhosis: Role of Hepatic and Non-Hepatic Influences
Effect of liver resection-induced increases in hepatic venous pressure gradient on development of postoperative acute kidney injury
Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology
Endovascular treatment of symptomatic hepatic venous outflow obstruction post major liver resection
Measurement of hepatic venous pressure gradient revisited: Catheter wedge vs balloon wedge techniques
Bone microarchitecture and bone turnover in hepatic cirrhosis
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Prognostic role of the hepatic venous pressure gradient in cirrhosis : [kumulative Habilitation]
Impact of catheter tip to hepatic vein ostium distance on the validity and prognostication of hepatic venous pressure gradient in cirrhosis
Impact of propofol sedation on the diagnostic accuracy of hepatic venous pressure gradient measurements in patients with cirrhosis
Hepatic caudate lobe resection
Glucose Intolerance in Liver Cirrhosis: Role of Hepatic and Non-Hepatic Influences
Effect of liver resection-induced increases in hepatic venous pressure gradient on development of postoperative acute kidney injury
Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology
Endovascular treatment of symptomatic hepatic venous outflow obstruction post major liver resection
Measurement of hepatic venous pressure gradient revisited: Catheter wedge vs balloon wedge techniques
Bone microarchitecture and bone turnover in hepatic cirrhosis
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