Tratamento da lesão muscular com células-tronco – Estudo experimental em coelhos

Abstract: Objective Histological and macroscopic evaluation of the healing process of acute lesions of the femoral rectus muscle using stem cells derived from adipose tissue-derived stem cells (ADSCs). Method An experimental study was conducted with 18 hind legs of New Zealand rabbits, which were divided into three study groups according to the intervention to be performed. In group I, no surgical procedure was performed; in group II—SHAN, the experimental lesion was performed without any additional intervention protocol; in group III—Intervention, the addition of ADSCs was performed in the same topography of the experimental lesion. After the proposed period, 2 weeks, the material was collected and submitted to macroscopic and histological evaluation. Results The quantitative analysis showed that the addition of ADSCs is related to the reduction of inflammatory cells in the 2-week evaluation (164.2 cells in group II - SHAN to 89.62 cells in group III - ADSC). The qualitative analysis of the slides with Picrosirius red, noticed an increase in orange/yellow fibers in group III - ADSC, which evidences a final healing process. The macroscopic evaluation found no difference between the groups. Conclusion The use of ADSCs in the treatment of acute muscle injury presented histological advantages when compared to their non-use.

Weitere Titel
Treatment of Muscle Injury with Stem Cells – Experimental Study in Rabbits
Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Portugiesisch

Erschienen in
Tratamento da lesão muscular com células-tronco – Estudo experimental em coelhos ; day:07 ; month:02 ; year:2022
Revista Brasileira de ortopedia ; (07.02.2022)

Beteiligte Personen und Organisationen
Santos, Alex de Lima
Silva, Camila Gonzaga da
Barreto, Leticia Siqueira de Sá
Tamaoki, Marcel Jun Sugawara
Pereira, Bruno Fiorelini
Almeida, Fernando Gonçalves de
Faloppa, Flavio

DOI
10.1055/s-0041-1741447
URN
urn:nbn:de:101:1-2022032413181192860399
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:19 MESZ

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Beteiligte

  • Santos, Alex de Lima
  • Silva, Camila Gonzaga da
  • Barreto, Leticia Siqueira de Sá
  • Tamaoki, Marcel Jun Sugawara
  • Pereira, Bruno Fiorelini
  • Almeida, Fernando Gonçalves de
  • Faloppa, Flavio

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