Tratamento da lesão muscular com células-tronco – Estudo experimental em coelhos
Abstract: Objective Histological and macroscopic evaluation of the healing process of acute lesions of the femoral rectus muscle using stem cells derived from adipose tissue-derived stem cells (ADSCs). Method An experimental study was conducted with 18 hind legs of New Zealand rabbits, which were divided into three study groups according to the intervention to be performed. In group I, no surgical procedure was performed; in group II—SHAN, the experimental lesion was performed without any additional intervention protocol; in group III—Intervention, the addition of ADSCs was performed in the same topography of the experimental lesion. After the proposed period, 2 weeks, the material was collected and submitted to macroscopic and histological evaluation. Results The quantitative analysis showed that the addition of ADSCs is related to the reduction of inflammatory cells in the 2-week evaluation (164.2 cells in group II - SHAN to 89.62 cells in group III - ADSC). The qualitative analysis of the slides with Picrosirius red, noticed an increase in orange/yellow fibers in group III - ADSC, which evidences a final healing process. The macroscopic evaluation found no difference between the groups. Conclusion The use of ADSCs in the treatment of acute muscle injury presented histological advantages when compared to their non-use.
- Weitere Titel
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Treatment of Muscle Injury with Stem Cells – Experimental Study in Rabbits
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Portugiesisch
- Erschienen in
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Tratamento da lesão muscular com células-tronco – Estudo experimental em coelhos ; day:07 ; month:02 ; year:2022
Revista Brasileira de ortopedia ; (07.02.2022)
- Beteiligte Personen und Organisationen
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Santos, Alex de Lima
Silva, Camila Gonzaga da
Barreto, Leticia Siqueira de Sá
Tamaoki, Marcel Jun Sugawara
Pereira, Bruno Fiorelini
Almeida, Fernando Gonçalves de
Faloppa, Flavio
- DOI
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10.1055/s-0041-1741447
- URN
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urn:nbn:de:101:1-2022032413181192860399
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:19 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Santos, Alex de Lima
- Silva, Camila Gonzaga da
- Barreto, Leticia Siqueira de Sá
- Tamaoki, Marcel Jun Sugawara
- Pereira, Bruno Fiorelini
- Almeida, Fernando Gonçalves de
- Faloppa, Flavio