Highlighting the Rich Chemistry of the Allenone Moiety

Abstract: Conjugated and non‐conjugated allenones appear as recurring motifs in organic synthesis, natural products and mechanistic investigations showing unique properties and applications. The ability of allenones to build cycles has provided a direct access to strained systems, medium‐sized rings, arenes, heterocycles and complex polycycles. In addition, allenones have served as models in mechanistic investigations and catalysis. The critic compilation herein presented will provide an exhaustive overview of the synthetic possibilities allenones may offer, which certainly will inspire our community in their search of more efficient synthetic methodologies, preparation of biological and pharmaceutical targets, and improve our knowledge in theoretical organic chemistry. Great part of this review will discuss synthetic aspects, catalysis innovation and mechanistic insights of the chemical transformations implying the allenone motif. In addition, many examples on total synthesis and pharmacologically active compounds will be described. We hope that this overview will be attractive to the organic chemistry, synthetic chemistry, catalysis, theoretical chemistry, natural products and medicinal chemistry communities.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Highlighting the Rich Chemistry of the Allenone Moiety ; volume:365 ; number:9 ; year:2023 ; pages:1332-1384 ; extent:53
Advanced synthesis & catalysis ; 365, Heft 9 (2023), 1332-1384 (gesamt 53)

Urheber
Alonso, José M.
Almendros, Pedro

DOI
10.1002/adsc.202300076
URN
urn:nbn:de:101:1-2023051315255371649256
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 10:46 MESZ

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Beteiligte

  • Alonso, José M.
  • Almendros, Pedro

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