Regioselective Localization and Tracking of Biomolecules on Single Gold Nanoparticles

Selective localization of biomolecules at the hot spots of a plasmonic nanoparticle is an attractive strategy to exploit the light–matter interaction due to the high field concentration. Current approaches for hot spot targeting are time‐consuming and involve prior knowledge of the hot spots. Multiphoton plasmonic lithography is employed to rapidly immobilize bovine serum albumin (BSA) hydrogel at the hot spot tips of a single gold nanotriangle (AuNT). Regioselectivity and quantity control by manipulating the polarization and intensity of the incident laser are also established. Single AuNTs are tracked using dark‐field scattering spectroscopy and scanning electron microscopy to characterize the regioselective process. Fluorescence lifetime measurements further confirm BSA immobilization on the AuNTs. Here, the AuNT‐BSA hydrogel complexes, in conjunction with single‐particle optical monitoring, can act as a framework for understanding light–molecule interactions at the subnanoparticle level and has potential applications in biophotonics, nanomedicine, and life sciences.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Regioselective Localization and Tracking of Biomolecules on Single Gold Nanoparticles ; volume:2 ; number:11 ; year:2015 ; extent:8 ; Advanced science ; 2, Heft 11 (2015) (gesamt 8)

Contributors, Places and Time

• Creator: Rajeeva, Bharath Bangalore ; Hernandez, Derek S. ; Wang, Mingsong ; Perillo, Evan ; Lin, Linhan ; Scarabelli, Leonardo ; Pingali, Bharadwaj ; Liz‐Marzán, Luis M. ; Dunn, Andrew K. ; Shear, Jason B. ; Zheng, Yuebing

Further information

• DOI: 10.1002/advs.201500232
• URN: urn:nbn:de:101:1-2022120506531447286292
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:24 AM CEST