Single Step Assembly of Janus Porous Biomaterial by Sub‐Ambient Temperature Electrodeposition

Abstract: Janus porous biomaterials are gaining increasing attention and there are considerable efforts to develop simple, rapid, and scalable methods capable of tuning micro‐ and macro‐structures. Here, a single‐step electro‐fabrication method to create a Janus porous film by the electrodeposition of the amino‐polysaccharide chitosan is reported. Specifically, a Janus structure emerges spontaneously when electrodeposition is performed at sub‐ambient temperature (0–5 °C). Sub‐ambient temperature electrodeposition experiments show that: a Janus microstructure emerges (potentially as the result of a subtle alteration of the intermolecular interactions responsible for self‐assembly); important microstructural features (pore size, porosity, and thicknesses) can be tuned by conditions; and this method is readily scalable (vs serial printing) and can yield complex tubular structures with Janus faces. In vitro studies demonstrate anisotropic cell guidance, and in vivo studies using a rat calvarial defect model further confirm the beneficial features of such Janus porous film for guided bone regeneration. In summary, these results further demonstrate that electro‐fabrication provides a simple and scalable platform technology for the controlled functional structures of soft matter for applications in regenerative medicine.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Single Step Assembly of Janus Porous Biomaterial by Sub‐Ambient Temperature Electrodeposition ; day:07 ; month:10 ; year:2022 ; extent:13 ; Small ; (07.10.2022) (gesamt 13)

Contributors, Places and Time

• Creator: Lei, Miao ; Liao, Haitao ; Wang, Shijia ; Zhou, Hang ; Zhao, Zhiling ; Payne, Gregory F. ; Qu, Xue ; Liu, Changsheng

Further information

• DOI: 10.1002/smll.202204837
• URN: urn:nbn:de:101:1-2022100815054563536392
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:33 AM CEST