Faecal calprotectin in inflammatory bowel diseases: a review focused on meta-analyses and routine usage limitations
Abstract: A growing body of evidence has been published about the usefulness of measuring calprotectin in faecal samples (FCAL) in inflammatory bowel disease (IBD) assessment, including diagnosis, monitoring of disease activity and relapse prediction. Several systematic reviews with meta-analyses compiling studies for each particular clinical setting have been carried out in recent years. Most of these were focused on the use of FCAL in IBD diagnosis and showed a relevant role for this marker in selecting patients with gastrointestinal symptoms who would not need a further examination by endoscopy. Although a lesser number of meta-analyses have been performed on the use of FCAL as a surrogate marker of disease activity, a close correlation between FCAL and endoscopic activity of IBD has been shown. With respect to the predictive capacity of FCAL for IBD relapse, a single meta-analysis published indicates that this role is more limited. Furthermore, FCAL thresholds vary considerably depending on the clinical setting and, what is more concerning, among different commercially available assays due to a lack of FCAL concentration interchangeability. Here, we summarise recent publications about the role and limitations of FCAL in IBD, with a special focus on meta-analyses, and give an overview of alternative faecal biomarkers.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Faecal calprotectin in inflammatory bowel diseases: a review focused on meta-analyses and routine usage limitations ; volume:57 ; number:9 ; year:2019 ; pages:1295-1307 ; extent:13
Clinical chemistry and laboratory medicine ; 57, Heft 9 (2019), 1295-1307 (gesamt 13)
- Urheber
-
Laserna-Mendieta, Emilio J.
Lucendo, Alfredo J.
- DOI
-
10.1515/cclm-2018-1063
- URN
-
urn:nbn:de:101:1-2022052011074861448084
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:31 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Laserna-Mendieta, Emilio J.
- Lucendo, Alfredo J.
Ähnliche Objekte (12)
Evaluation of a faecal calprotectin method using the OC-SENSOR PLEDIA
Pre-diagnostic faecal calprotectin levels in patients with colorectal cancer: a retrospective study
Analytical performance and diagnostic accuracy of six different faecal calprotectin assays in inflammatory bowel disease
The strengths and limitations of meta-analyses based on aggregate data
Impact of diets with a high content of greaves-meal protein or carbohydrates on faecal characteristics, volatile fatty acids and faecal calprotectin concentrations in healthy dogs
Diagnostic yield of endoscopy in patients with abdominal complaints: incremental value of faecal calprotectin on guidelines of appropriateness
The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis
Elevated Faecal Calprotectin in Patients with a Normal Colonoscopy: Does It Matter in Clinical Practice? A Retrospective Observational Study
Faecal calprotectin concentrations in apparently healthy children aged 0-12 years in urban Kampala, Uganda: a community-based survey
Faecal calprotectin is the biomarker that best distinguishes remission from different degrees of endoscopic activity in Crohn’s disease
Calprotectin bei mikroskopischer Kolitis
Calprotectin in Cystic Fibrosis
Evaluation of a faecal calprotectin method using the OC-SENSOR PLEDIA
Pre-diagnostic faecal calprotectin levels in patients with colorectal cancer: a retrospective study
Analytical performance and diagnostic accuracy of six different faecal calprotectin assays in inflammatory bowel disease
The strengths and limitations of meta-analyses based on aggregate data
Impact of diets with a high content of greaves-meal protein or carbohydrates on faecal characteristics, volatile fatty acids and faecal calprotectin concentrations in healthy dogs
Diagnostic yield of endoscopy in patients with abdominal complaints: incremental value of faecal calprotectin on guidelines of appropriateness
The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis
Elevated Faecal Calprotectin in Patients with a Normal Colonoscopy: Does It Matter in Clinical Practice? A Retrospective Observational Study
Faecal calprotectin concentrations in apparently healthy children aged 0-12 years in urban Kampala, Uganda: a community-based survey
Faecal calprotectin is the biomarker that best distinguishes remission from different degrees of endoscopic activity in Crohn’s disease
Calprotectin bei mikroskopischer Kolitis
Calprotectin in Cystic Fibrosis
Evaluation of a faecal calprotectin method using the OC-SENSOR PLEDIA
Pre-diagnostic faecal calprotectin levels in patients with colorectal cancer: a retrospective study
Analytical performance and diagnostic accuracy of six different faecal calprotectin assays in inflammatory bowel disease
The strengths and limitations of meta-analyses based on aggregate data
Impact of diets with a high content of greaves-meal protein or carbohydrates on faecal characteristics, volatile fatty acids and faecal calprotectin concentrations in healthy dogs
Diagnostic yield of endoscopy in patients with abdominal complaints: incremental value of faecal calprotectin on guidelines of appropriateness
The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis
Elevated Faecal Calprotectin in Patients with a Normal Colonoscopy: Does It Matter in Clinical Practice? A Retrospective Observational Study
Faecal calprotectin concentrations in apparently healthy children aged 0-12 years in urban Kampala, Uganda: a community-based survey
Faecal calprotectin is the biomarker that best distinguishes remission from different degrees of endoscopic activity in Crohn’s disease
Calprotectin bei mikroskopischer Kolitis