Collagen/glycosaminoglycan-based matrices for controlling skin cell responses
Abstract: Wound healing and tissue regeneration are orchestrated by the cellular microenvironment, e.g. the extracellular matrix (ECM). Including ECM components in biomaterials is a promising approach for improving regenerative processes, e.g. wound healing in skin. This review addresses recent findings for enhanced epidermal-dermal regenerative processes on collagen (coll)/glycosaminoglycan (GAG)-based matrices containing sulfated GAG (sGAG) in simple and complex in vitro models. These matrices comprise 2D-coatings, electrospun nanofibrous scaffolds, and photo-crosslinked acrylated hyaluronan (HA-AC)/coll-based hydrogels. They demonstrated to regulate keratinocyte and fibroblast migration and growth, to stimulate melanogenesis in melanocytes from the outer root sheath (ORS) of hair follicles and to enhance the epithelial differentiation of human mesenchymal stem cells (hMSC). The matrices’ suitability for delivery of relevant growth factors, like heparin-binding epidermal growth factor like growth factor (HB-EGF), further highlights their potential as bioinspired, functional microenvironments for enhancing skin regeneration.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Collagen/glycosaminoglycan-based matrices for controlling skin cell responses ; volume:402 ; number:11 ; year:2021 ; pages:1325-1335 ; extent:11
Biological chemistry ; 402, Heft 11 (2021), 1325-1335 (gesamt 11)
- Creator
- DOI
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10.1515/hsz-2021-0176
- URN
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urn:nbn:de:101:1-2408061626139.076705081020
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:53 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Anderegg, Ulf
- Halfter, Norbert
- Schnabelrauch, Matthias
- Hintze, Vera
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Type II collagen and glycosaminoglycan expression induction in primary human chondrocyte by TGF-β1
Prevascularization of collagen-glycosaminoglycan scaffolds: stromal vascular fraction versus adipose tissue-derived microvascular fragments
Funktionen von Decorin und seiner Glycosaminoglycan-Kette bei der Collagen-Fibrillogenese in einem dreidimensionalen Matrixmodell
Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study
Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis
IR action spectroscopy of glycosaminoglycan oligosaccharides
Utility Of Collagen Sheet As Skin Substitute
Glycosaminoglycan Concentration and Sulfation Patterns of Biohybrid Polymer Matrices Direct Microvascular Network Formation and Stability
Endogenous glycosaminoglycan anticoagulation in extracorporeal membrane oxygenation
Porcine dentin sialoprotein glycosylation and glycosaminoglycan attachments
The healing effect of the collagen-glycosaminoglycan copolymer on corneal thinning
A self-organising biomimetic collagen/nano-hydroxyapatite-glycosaminoglycan scaffold for spinal fusion
Type II collagen and glycosaminoglycan expression induction in primary human chondrocyte by TGF-β1
Prevascularization of collagen-glycosaminoglycan scaffolds: stromal vascular fraction versus adipose tissue-derived microvascular fragments
Funktionen von Decorin und seiner Glycosaminoglycan-Kette bei der Collagen-Fibrillogenese in einem dreidimensionalen Matrixmodell
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Glycosaminoglycan Concentration and Sulfation Patterns of Biohybrid Polymer Matrices Direct Microvascular Network Formation and Stability
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