Pregnancy-Associated Onset of Adult-Onset Still's Disease

Abstract: Objective This study aims to elucidate the clinical manifestations, diagnostic challenges, and management strategies of adult-onset Still's disease (AOSD) during pregnancy, leveraging a case series overview and a detailed case report from our center. Study Design A comprehensive review of 21 published case reports on AOSD diagnosed during pregnancy was conducted, alongside a detailed case report of a patient diagnosed and managed at our center. This study emphasizes the importance of recognizing AOSD in pregnant patients, outlines the therapeutic challenges encountered, and discusses the potential complications arising from the disease and its treatment. Results The onset of AOSD during pregnancy predominantly occurs in the first or second trimester, with a polycyclic disease course observed in most cases. Management primarily involves corticosteroids and immunosuppressive medications, balancing the disease control with potential pregnancy complications. The case report highlights the complex interplay between AOSD, hemophagocytic lymphohistiocytosis, and pregnancy, illustrating a multidisciplinary approach to management that ensured favorable maternal and fetal outcomes despite the significant challenges. Conclusion AOSD presents unique diagnostic and therapeutic challenges during pregnancy, requiring careful consideration of maternal and fetal health. Early diagnosis, a multidisciplinary approach to care, and judicious use of immunosuppressive therapy are critical for managing AOSD flares and associated complications. Further research is necessary to optimize care for this rare condition in the context of pregnancy.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Pregnancy-Associated Onset of Adult-Onset Still's Disease ; volume:14 ; number:02 ; year:2024 ; pages:e145-e155 ; AJP reports ; 14, Heft 02 (2024), e145-e155

Beteiligte, Orts- und Zeitangaben

• Beteiligte Personen und Organisationen: Zayat, Nawras ; Arora, Avish ; O'Brien, Joselle ; Bal, Japjot ; Sugarman, Rebekah ; Rivera, Leeshun ; Shamshirsaz, Amir ; Vani, Kavita ; Mastrogiannis, Dimitrios S.

Weitere Informationen

• DOI: 10.1055/a-2318-0305
• URN: urn:nbn:de:101:1-2407111411589.408465251885
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:44 MESZ