Small Molecular Inhibitors Reverse Cancer Metastasis by Blockading Oncogenic PITPNM3
Abstract: Most cancer‐related deaths are a result of metastasis. The development of small molecular inhibitors reversing cancer metastasis represents a promising therapeutic opportunity for cancer patients. This pan‐cancer analysis identifies oncogenic roles of membrane‐associated phosphatidylinositol transfer protein 3 (PITPNM3), which is crucial for cancer metastasis. Small molecules targeting PITPNM3 must be explored further. Here, PITPNM3‐selective small molecular inhibitors are reported. These compounds exhibit target‐specific inhibition of PITPNM3 signaling, thereby reducing metastasis of breast cancer cells. Besides, by using nanoparticle‐based delivery systems, these PITPNM3‐selective compounds loaded nanoparticles significantly repress metastasis of breast cancer in mouse xenograft models and organoid models. Notably, the results establish an important metastatic‐promoting role for PITPNM3 and offer PITPNM3 inhibition as a therapeutic strategy in metastatic breast cancer.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Small Molecular Inhibitors Reverse Cancer Metastasis by Blockading Oncogenic PITPNM3 ; day:26 ; month:10 ; year:2022 ; extent:11
Advanced science ; (26.10.2022) (gesamt 11)
- Urheber
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Liu, Zihao
Shi, Yu
Lv, Li
Chen, Jianing
Jiang, WenG.
Li, Jun
Lin, Qun
Fang, Xiaolin
Gao, Jingbo
Liu, Yujie
Liu, Qiang
Xu, Xiaoding
Song, Erwei
Gong, Chang
- DOI
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10.1002/advs.202204649
- URN
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urn:nbn:de:101:1-2022102615555502665669
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:33 MESZ
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Beteiligte
- Liu, Zihao
- Shi, Yu
- Lv, Li
- Chen, Jianing
- Jiang, WenG.
- Li, Jun
- Lin, Qun
- Fang, Xiaolin
- Gao, Jingbo
- Liu, Yujie
- Liu, Qiang
- Xu, Xiaoding
- Song, Erwei
- Gong, Chang
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