CLERC and centrosomal leucine-rich repeat proteins
Abstract: The centrosome functions as the microtubule-organizing center and plays a vital role in organizing spindle poles during mitosis. Recently, we identified a centrosomal protein called CLERC (Centrosomal leucine-rich repeat and coiled-coil containing protein) which is a human ortholog of Chlamydomonas Vfl1 protein. The bibliography as well as database searches provided evidence that the human proteome contains at least seven centrosomal leucine-rich repeat proteins including CLERC. CLERC and four other centrosomal leucine-rich repeat proteins contain the SDS22-like leucine-rich repeat motifs, whereas the remaining two proteins contain the RI-like and the cysteine-containing leucine-rich repeat motifs. Individual leucine-rich repeat motifs are highly conserved and present in evolutionarily diverse organisms. Here, we provide an overview of CLERC and other centrosomal leucine-rich repeat proteins, their structures, their evolutionary relationships, and their functional properties.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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CLERC and centrosomal leucine-rich repeat proteins ; volume:5 ; number:1 ; year:2010 ; pages:1-10 ; extent:10
Open life sciences ; 5, Heft 1 (2010), 1-10 (gesamt 10)
- Urheber
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Muto, Yoshinori
Okano, Yukio
- DOI
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10.2478/s11535-009-0061-x
- URN
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urn:nbn:de:101:1-2409201850480.683632432593
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 15.08.2025, 07:34 MESZ
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Beteiligte
- Muto, Yoshinori
- Okano, Yukio
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