Poly (Sarcosine) Surface Modification Imparts Stealth‐Like Properties to Liposomes
Abstract: Circulation lifetime is a crucial parameter for a successful therapy with nanoparticles. Reduction and alteration of opsonization profiles by surface modification of nanoparticles is the main strategy to achieve this objective. In clinical settings, PEGylation is the most relevant strategy to enhance blood circulation, yet it has drawbacks, including hypersensitivity reactions in some patients treated with PEGylated nanoparticles, which fuel the search for alternative strategies. In this work, lipopolysarcosine derivatives (BA‐pSar, bisalkyl polysarcosine) with precise chain lengths and low polydispersity indices are synthesized, characterized, and incorporated into the bilayer of preformed liposomes via a post insertion technique. Successful incorporation of BA‐pSar can be realized in a clinically relevant liposomal formulation. Furthermore, BA‐pSar provides excellent surface charge shielding potential for charged liposomes and renders their surface neutral. Pharmacokinetic investigations in a zebrafish model show enhanced circulation properties and reduction in macrophage recognition, matching the behavior of PEGylated liposomes. Moreover, complement activation, which is a key factor in hypersensitivity reactions caused by PEGylated liposomes, can be reduced by modifying the surface of liposomes with an acetylated BA‐pSar derivative. Hence, this study presents an alternative surface modification strategy with similar benefits as the established PEGylation of nanoparticles, but with the potential of reducing its drawbacks.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Poly (Sarcosine) Surface Modification Imparts Stealth‐Like Properties to Liposomes ; volume:15 ; number:50 ; year:2019 ; extent:10
Small ; 15, Heft 50 (2019) (gesamt 10)
- Creator
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Bleher, Stefan
Buck, Jonas
Muhl, Christian
Sieber, Sandro
Barnert, Sabine
Witzigmann, Dominik
Huwyler, Jörg
Barz, Matthias
Süss, Regine
- DOI
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10.1002/smll.201904716
- URN
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urn:nbn:de:101:1-2022072906334163598077
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:38 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Bleher, Stefan
- Buck, Jonas
- Muhl, Christian
- Sieber, Sandro
- Barnert, Sabine
- Witzigmann, Dominik
- Huwyler, Jörg
- Barz, Matthias
- Süss, Regine
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Differences in Human Plasma Protein Interactions between Various Polymersomes and Stealth Liposomes as Observed by Fluorescence Correlation Spectroscopy
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Targeting doxorubicin encapsulated in stealth liposomes to solid tumors by non thermal diode laser
Multifunctional liposomes: Microscale formulation, modification and in vitro interaction
Stealth multiboson signals
Stealth DoS
Stealth Supersymmetry simplified
Differences in Human Plasma Protein Interactions between Various Polymersomes and Stealth Liposomes as Observed by Fluorescence Correlation Spectroscopy
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