Protein Grafting Techniques: From Peptide Epitopes to Lasso‐Grafted Neobiologics
Abstract: Protein engineering techniques have vastly expanded their domain of impact, notably following the success of antibodies. Likewise, smaller peptide therapeutics have carved an increasingly significant niche for themselves in the pharmaceutical landscape. The concept of grafting such peptides onto larger protein scaffolds, thus harvesting the advantages of both, has given rise to a variety of protein engineering strategies that are reviewed herein. We also describe our own “Lasso‐Grafting” approach, which combines traditional grafting concepts with mRNA display to streamline the production of multiple grafted drug candidates for virtually any target.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Protein Grafting Techniques: From Peptide Epitopes to Lasso‐Grafted Neobiologics ; day:27 ; month:05 ; year:2024 ; extent:14
ChemPlusChem ; (27.05.2024) (gesamt 14)
- Urheber
- DOI
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10.1002/cplu.202400152
- URN
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urn:nbn:de:101:1-2405281406476.499374772589
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 14.08.2025, 10:57 MESZ
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Beteiligte
- Imai, Mikio
- Colas, Kilian
- Suga, Hiroaki
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