Synthesis and biological evaluation of novel 4-oxo-5-cyano thiouracil derivatives as SecA inhibitors
Abstract: The continuous emergence of drug-resistant strains of bacteria poses an urgent risk to human health and dictates the need for new antimicrobials. Along this line, we have been working on developing inhibitors of SecA, a key component of the bacterial Sec-dependent secretion machinery. Herein, we describe the synthesis and antimicrobial evaluation of 6-oxo-1,6-dihydropyrimidine-5-carbonitrile derivatives as potential SecA inhibitors.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Synthesis and biological evaluation of novel 4-oxo-5-cyano thiouracil derivatives as SecA inhibitors ; volume:26 ; number:1 ; year:2020 ; pages:76-83 ; extent:8
Heterocyclic communications ; 26, Heft 1 (2020), 76-83 (gesamt 8)
- Creator
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Bamba, Fante
Jin, Jinshan
Tai, Phang C.
Wang, Binghe
- DOI
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10.1515/hc-2020-0100
- URN
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urn:nbn:de:101:1-2501140311038.545573543198
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:29 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Bamba, Fante
- Jin, Jinshan
- Tai, Phang C.
- Wang, Binghe
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