Deficiency of NPGP x, an oxidative stress sensor, leads to obesity in mice and human
Elevated oxidative stress is closely associated with obesity. Emerging evidence shows that instead of being a consequence of obesity, oxidative stress may also contribute to fat formation. Nonselenocysteine‐containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) is a conserved oxidative stress sensor/transducer and deficiency of NPGPx causes accumulation of reactive oxygen species (ROS). In this communication, we show that NPGPx was highly expressed in preadipocytes of adipose tissue. Deficiency of NPGPx promoted preadipocytes to differentiate to adipocytes via ROS‐dependent dimerization of protein kinase A regulatory subunits and activation of CCAAT/enhancer‐binding protein beta (C/EBPβ). This enhanced adipogenesis was alleviated by antioxidant N‐acetylcysteine (NAC). Consistently, NPGPx‐deficient mice exhibited markedly increased fat mass and adipocyte hypertrophy, while treatment with NAC ablated these phenotypes. Furthermore, single nucleotide polymorphisms (SNPs) in human NPGPx gene, which correlated with lower NPGPx expression level in adipose tissue, were associated with higher body mass index (BMI) in several independent human populations. These results indicate that NPGPx protects against fat accumulation in mice and human via modulating ROS, and highlight the importance of targeting redox homeostasis in obesity management.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Deficiency of NPGP x, an oxidative stress sensor, leads to obesity in mice and human ; volume:5 ; number:8 ; year:2013 ; pages:1165-1179 ; extent:15
EMBO molecular medicine / European Molecular Biology Organization ; 5, Heft 8 (2013), 1165-1179 (gesamt 15)
- Urheber
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Chang, Yi‐Cheng
Yu, Yu‐Hsiang
Shew, Jin‐Yuh
Lee, Wei‐Jei
Hwang, Juey‐Jen
Chen, Yen‐Hui
Chen, Yet‐Ran
Wei, Pei‐Chi
Chuang, Lee‐Ming
Lee, Wen‐Hwa
- DOI
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10.1002/emmm.201302679
- URN
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urn:nbn:de:101:1-2023020306135800477980
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:23 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Chang, Yi‐Cheng
- Yu, Yu‐Hsiang
- Shew, Jin‐Yuh
- Lee, Wei‐Jei
- Hwang, Juey‐Jen
- Chen, Yen‐Hui
- Chen, Yet‐Ran
- Wei, Pei‐Chi
- Chuang, Lee‐Ming
- Lee, Wen‐Hwa
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