Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films
Abstract: In this study, composite nanofiber films for the wound dressing application were prepared with silk fibroin (SF) and polycaprolactone (PCL) by electrospinning techniques, and the SF/PCL composite nanofiber films were characterized by the combined techniques of scanning electron microscopy (SEM), the equilibrium water content, Fourier transform infrared spectrometer test, X-ray diffraction (XRD) and cell viability test. The results indicated several parameters, including the rotating roller speed, solution concentration, and SF/PCL ratio, affected SF/PCL composite nanofibers’ diameter size, distribution, and wettability. The SF/PCL composite nanofiber manifested a smaller fiber diameter and more uniform nanofibers than pure PCL nanofibers. The contact angle changed from 121 ± 2° of the neat pure PCL to full wetting of 40% SF/PCL composite nanofiber films at 2,000 rpm, indicating good hydrophilicity. Meanwhile, cells exhibit adhesion and proliferation on the composite nanofiber films. These results testified that SF/PCL composite nanofiber films may provide good wettability for cell adhesion and proliferation. It was suggested that optimized SF/PCL composite nanofiber films could be used as a potential biological dressing for skin wound healing.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films ; volume:62 ; number:1 ; year:2023 ; extent:9
Reviews on advanced materials science ; 62, Heft 1 (2023) (gesamt 9)
- Urheber
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Feng, Yanping
Jupei, Zhang
Dong, Zhihong
Tang, Lu
- DOI
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10.1515/rams-2022-0333
- URN
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urn:nbn:de:101:1-2023071214151377396982
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:00 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Feng, Yanping
- Jupei, Zhang
- Dong, Zhihong
- Tang, Lu
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