Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting

Pyoderma gangrenosum (PG) is a relatively rare inflammatory skin disease that progressively causes necrotic ulceration mainly on the lower extremities and trunk. Systemic corticosteroid is considered a first-line treatment for PG as it facilitates wound healing; however, several cases where tumor necrosis factor-α inhibitors, adalimumab and infliximab, were administered showed good response. For intractable PG with a large ulcer or problematic epithelization, chemical or mechanical debridement of necrotic tissue in combination with skin grafting may be necessary to promote wound healing. Our report presents a case of intractable ulcerative PG requiring oral prednisolone and skin grafting. Although mechanical debridement was performed, granulation was poor; therefore, after the PG activity became quiescent, we utilized a vacuum-assisted closure (VAC) system to promote granulation and adaptation of the grafted skin. Although more cases are required for a definitive conclusion, the VAC system may be a choice for PG with large ulcers.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting ; volume:13 ; number:3 ; year:2021 ; pages:497-501 ; extent:5 ; Case reports in dermatology ; 13, Heft 3 (2021), 497-501 (gesamt 5)

Beteiligte, Orts- und Zeitangaben

• Urheber: Goto, Hiroyuki ; Okada, Yoshimoto ; Watanabe, Seimi ; Danno, Kanako ; Yamamoto, Shinya ; Ishiura, Ryohei ; Nakayama, Yuichi ; Mitsui, Kohei ; Ueki, Ayaka ; Nakai, Yasuo ; Narushima, Mitsunaga ; Yamanaka, Keiichi

Weitere Informationen

• DOI: 10.1159/000519659
• URN: urn:nbn:de:101:1-2022011300032026355791
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:19 MESZ