Nanofiber‐Coated CF/PEEK Composite: Boosting Osteogenesis for Enhanced Bone Grafting

Abstract: This study presents the fabrication of carbon‐fiber‐reinforced polyetheretherketone (CF/PEEK) by 3D printing, which is subsequently coated with elastic nanofibers by electrospinning. CF/PEEK is an FDA‐approved implantable material possessing excellent mechanical properties similar to those of human cortical bone. As such, it is a prime candidate for replacing conventional metallic implants. However, it is limited by its bioinertness and inferior osteogenic properties. In this study, CF/PEEK is engineered to have improved hydrophilic properties and generated micro/nano‐topographical structures on its surface. This is achieved by electrospinning directly onto the 3D‐printed CF/PEEK with fibers incorporating hydroxyapatite particles and gelatin. The results show that the micro‐/nano‐topographical CF/PEEK demonstrates a significant increase in mineralizing potential compared to non‐coated implants, where no mineralized matrix is observed. These fiber coating modifications to CF/PEEK are a promising and important step forward in the improvement of in vivo implant‐bone osteointegration.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Nanofiber‐Coated CF/PEEK Composite: Boosting Osteogenesis for Enhanced Bone Grafting ; day:30 ; month:10 ; year:2024 ; extent:6 ; Macromolecular materials and engineering ; (30.10.2024) (gesamt 6)

Beteiligte, Orts- und Zeitangaben

• Urheber: Yang, Dan‐Lei ; Stephen, Louise A. ; Qayyum, Junaid Ahmad ; Yang, Dongmin ; Farquharson, Colin ; Radacsi, Norbert

Weitere Informationen

• DOI: 10.1002/mame.202400286
• URN: urn:nbn:de:101:1-2410311311377.877456054198
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:34 MESZ