Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
Abstract: Increasing resistance against antimycotic drugs challenges anti‐infective therapies today and contributes to the mortality of infections by drug‐resistant Candida species and strains. Therefore, novel antifungal agents are needed. A promising approach in developing new drugs is using naturally occurring molecules as lead structures. In this work, 4,4'‐dihydroxyazobenzene, a compound structurally related to antifungal stilbene derivatives and present in Agaricus xanthodermus (yellow stainer), served as a starting point for the synthesis of five azobenzene derivatives. These compounds prevented the growth of both fluconazole‐susceptible and fluconazole‐resistant Candida albicans and Candida auris strains. Further in vivo studies are required to confirm the potential therapeutic value of these compounds.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris ; day:20 ; month:11 ; year:2022 ; extent:7
Archiv der Pharmazie ; (20.11.2022) (gesamt 7)
- Urheber
-
Raschig, Martina
Ramírez‐Zavala, Bernardo
Wiest, Johannes
Saedtler, Marco
Gutmann, Marcus
Holzgrabe, Ulrike
Morschhäuser, Joachim
Meinel, Lorenz
- DOI
-
10.1002/ardp.202200463
- URN
-
urn:nbn:de:101:1-2022112114083618451791
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 15.08.2025, 07:30 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Raschig, Martina
- Ramírez‐Zavala, Bernardo
- Wiest, Johannes
- Saedtler, Marco
- Gutmann, Marcus
- Holzgrabe, Ulrike
- Morschhäuser, Joachim
- Meinel, Lorenz
Ähnliche Objekte (12)
Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
![Oxidative Cyclisierung von N-Benzyl-β-aminoketonen [N-Benzyl-beta-aminoketonen] mit Cer(IV)sulfat [Cersulfat] zu 1,2,3,4-Tetrahydroisochinolinen [Tetrahydroisochinolinen]](/assets/placeholder/searchResultMediaNoDigitisedMedia.png)
Oxidative Cyclisierung von N-Benzyl-β-aminoketonen [N-Benzyl-beta-aminoketonen] mit Cer(IV)sulfat [Cersulfat] zu 1,2,3,4-Tetrahydroisochinolinen [Tetrahydroisochinolinen]
Antihypertensiva
Palliativmedizin
Antiarrhythmika
Analysis of histamine and sisomicin in gentamicin: Search for the causative agents of adverse effects
Antimykotikaresistenzen bei deutschen Candida auris Isolaten
Analysis of histamine and sisomicin in gentamicin: search for the causative agents of adverse effects
Quantitative NMR-Spektroskopie in der pharmazeutischen Analytik [[Elektronische Ressource]] : Identität, Reinheit und Gehalt von Arzneistoffen
Development of practice-oriented LC-MS, MS methods for the determination of important drugs and their application for building PK, PD concepts
Klimakterium : 125 Jahre DPhG
Antileishmanial compounds from Nature - Elucidation of the active principles of an extract from Valeriana wallichii rhizomes
Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
Oxidative Cyclisierung von N-Benzyl-β-aminoketonen [N-Benzyl-beta-aminoketonen] mit Cer(IV)sulfat [Cersulfat] zu 1,2,3,4-Tetrahydroisochinolinen [Tetrahydroisochinolinen]
Antihypertensiva
Palliativmedizin
Antiarrhythmika
Analysis of histamine and sisomicin in gentamicin: Search for the causative agents of adverse effects
Antimykotikaresistenzen bei deutschen Candida auris Isolaten
Analysis of histamine and sisomicin in gentamicin: search for the causative agents of adverse effects
Quantitative NMR-Spektroskopie in der pharmazeutischen Analytik [[Elektronische Ressource]] : Identität, Reinheit und Gehalt von Arzneistoffen
Development of practice-oriented LC-MS, MS methods for the determination of important drugs and their application for building PK, PD concepts
Klimakterium : 125 Jahre DPhG
Antileishmanial compounds from Nature - Elucidation of the active principles of an extract from Valeriana wallichii rhizomes
Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
Oxidative Cyclisierung von N-Benzyl-β-aminoketonen [N-Benzyl-beta-aminoketonen] mit Cer(IV)sulfat [Cersulfat] zu 1,2,3,4-Tetrahydroisochinolinen [Tetrahydroisochinolinen]
Antihypertensiva
Palliativmedizin
Antiarrhythmika
Analysis of histamine and sisomicin in gentamicin: Search for the causative agents of adverse effects
Antimykotikaresistenzen bei deutschen Candida auris Isolaten
Analysis of histamine and sisomicin in gentamicin: search for the causative agents of adverse effects
Quantitative NMR-Spektroskopie in der pharmazeutischen Analytik [[Elektronische Ressource]] : Identität, Reinheit und Gehalt von Arzneistoffen
Development of practice-oriented LC-MS, MS methods for the determination of important drugs and their application for building PK, PD concepts
Klimakterium : 125 Jahre DPhG