Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
Abstract: Increasing resistance against antimycotic drugs challenges anti‐infective therapies today and contributes to the mortality of infections by drug‐resistant Candida species and strains. Therefore, novel antifungal agents are needed. A promising approach in developing new drugs is using naturally occurring molecules as lead structures. In this work, 4,4'‐dihydroxyazobenzene, a compound structurally related to antifungal stilbene derivatives and present in Agaricus xanthodermus (yellow stainer), served as a starting point for the synthesis of five azobenzene derivatives. These compounds prevented the growth of both fluconazole‐susceptible and fluconazole‐resistant Candida albicans and Candida auris strains. Further in vivo studies are required to confirm the potential therapeutic value of these compounds.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris ; day:20 ; month:11 ; year:2022 ; extent:7
Archiv der Pharmazie ; (20.11.2022) (gesamt 7)
- Creator
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Raschig, Martina
Ramírez‐Zavala, Bernardo
Wiest, Johannes
Saedtler, Marco
Gutmann, Marcus
Holzgrabe, Ulrike
Morschhäuser, Joachim
Meinel, Lorenz
- DOI
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10.1002/ardp.202200463
- URN
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urn:nbn:de:101:1-2022112114083618451791
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 15.08.2025, 7:30 AM CEST
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Associated
- Raschig, Martina
- Ramírez‐Zavala, Bernardo
- Wiest, Johannes
- Saedtler, Marco
- Gutmann, Marcus
- Holzgrabe, Ulrike
- Morschhäuser, Joachim
- Meinel, Lorenz
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Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
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