Pro‐ and antitumorigenic functions of γδ T cells
Abstract: γδ T cells are a subset of T cells that are characterized by the expression of a TCR‐γδ instead of a TCR‐αβ. Despite being outnumbered by their αβ T cell counterpart in many tissues, studies from the last 20 years underline their important and non‐redundant roles in tumor and metastasis development. However, whether a γδ T cell exerts pro‐ or antitumorigenic effects seems to depend on a variety of factors, many of them still incompletely understood today. In this review, we summarize mechanisms by which γδ T cells exert these seemingly contradictory effector functions in mice and humans. Furthermore, we discuss the current view on inducing and inhibiting factors of γδ T cells during cancer development.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Pro‐ and antitumorigenic functions of γδ T cells ; day:27 ; month:05 ; year:2024 ; extent:9
European journal of immunology ; (27.05.2024) (gesamt 9)
- Creator
- DOI
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10.1002/eji.202451070
- URN
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urn:nbn:de:101:1-2405281412204.285612133865
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:48 AM CEST
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Associated
- Fiala, Gina Jasmin
- Lücke, Jöran
- Huber, Samuel
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