Lipopolysaccharides promote pulmonary fibrosis in silicosis through the aggravation of apoptosis and inflammation in alveolar macrophages
Abstract: Alveolar macrophages (AMs) play an important defensive role by removing dust and bacteria from alveoli. Apoptosis of AMs is associated with lung fibrosis; however, the relationship between this apoptotic event and environmental factors, such as the presence of lipopolysaccharides (LPSs) in the workplace, has not yet been addressed. To investigate whether exposure to LPS can exacerbate fibrosis, we collected AMs from 12 male workers exposed to silica and incubated them in the presence and absence of LPS for 24 h. We show that the levels of cleaved caspase-3 and pro-inflammatory cytokines interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha were increased in these AMs following LPS treatment. Moreover, we demonstrate that LPS exposure aggravated apoptosis and the release of inflammatory factors in AMs in a mouse model of silicosis, which eventually promoted pulmonary fibrosis. These results suggest that exposure to LPS may accelerate the progression of pulmonary fibrosis in silicosis by increasing apoptosis and inflammation in AMs.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Lipopolysaccharides promote pulmonary fibrosis in silicosis through the aggravation of apoptosis and inflammation in alveolar macrophages ; volume:15 ; number:1 ; year:2020 ; pages:598-605 ; extent:8
Open life sciences ; 15, Heft 1 (2020), 598-605 (gesamt 8)
- Creator
-
Tan, Shiyi
Yang, Shang
Chen, Mingke
Wang, Yurun
Zhu, Li
Sun, Zhiqian
Chen, Shi
- DOI
-
10.1515/biol-2020-0061
- URN
-
urn:nbn:de:101:1-2409201702418.742905737854
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:28 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Tan, Shiyi
- Yang, Shang
- Chen, Mingke
- Wang, Yurun
- Zhu, Li
- Sun, Zhiqian
- Chen, Shi
Other Objects (12)
Da ban ruo po luo mi duo jing : 407. juan
Research on tax compliance incentive effects of platform companies from the perspective of incomplete contract: An empirical study based on China
Solving nonlinear Volterra integro-differential equations of fractional order by using Euler wavelet method
A new intrusion detection and alarm correlation technology based on neural network
Interfacial instability of ferrofluid flow under the influence of a vacuum magnetic field
Network pharmacological prediction of the mechanism of action of Shen-Zhu-Lian-Bai Decoction in the treatment of ulcerative colitis
Hydride units filled boron–carbon clathrate: a pathway for high-temperature superconductivity at ambient pressure
The SOFM-based city-type identification and scan of 231 cities in the APEC region
The impacts of health insurance on financial strain for people with chronic diseases
Regularization Approach for Network Modeling of German Energy Market
The common and speci fic components of inflation expectation across European countries
Bank interest margin, multiple shadow banking activities, and capital regulation
Da ban ruo po luo mi duo jing : 407. juan
Research on tax compliance incentive effects of platform companies from the perspective of incomplete contract: An empirical study based on China
Solving nonlinear Volterra integro-differential equations of fractional order by using Euler wavelet method
A new intrusion detection and alarm correlation technology based on neural network
Interfacial instability of ferrofluid flow under the influence of a vacuum magnetic field
Network pharmacological prediction of the mechanism of action of Shen-Zhu-Lian-Bai Decoction in the treatment of ulcerative colitis
Hydride units filled boron–carbon clathrate: a pathway for high-temperature superconductivity at ambient pressure
The SOFM-based city-type identification and scan of 231 cities in the APEC region
The impacts of health insurance on financial strain for people with chronic diseases
Regularization Approach for Network Modeling of German Energy Market
The common and speci fic components of inflation expectation across European countries
Bank interest margin, multiple shadow banking activities, and capital regulation
Da ban ruo po luo mi duo jing : 407. juan
Research on tax compliance incentive effects of platform companies from the perspective of incomplete contract: An empirical study based on China
Solving nonlinear Volterra integro-differential equations of fractional order by using Euler wavelet method
A new intrusion detection and alarm correlation technology based on neural network
Interfacial instability of ferrofluid flow under the influence of a vacuum magnetic field
Network pharmacological prediction of the mechanism of action of Shen-Zhu-Lian-Bai Decoction in the treatment of ulcerative colitis
Hydride units filled boron–carbon clathrate: a pathway for high-temperature superconductivity at ambient pressure
The SOFM-based city-type identification and scan of 231 cities in the APEC region
The impacts of health insurance on financial strain for people with chronic diseases
Regularization Approach for Network Modeling of German Energy Market
The common and speci fic components of inflation expectation across European countries