Radiotherapy‐Induced Astrocyte Senescence Promotes an Immunosuppressive Microenvironment in Glioblastoma to Facilitate Tumor Regrowth
Abstract: Accumulating evidence suggests that changes in the tumor microenvironment caused by radiotherapy are closely related to the recurrence of glioma. However, the mechanisms by which such radiation‐induced changes are involved in tumor regrowth have not yet been fully investigated. In the present study, how cranial irradiation‐induced senescence in non‐neoplastic brain cells contributes to glioma progression is explored. It is observed that senescent brain cells facilitated tumor regrowth by enhancing the peripheral recruitment of myeloid inflammatory cells in glioblastoma. Further, it is identified that astrocytes are one of the most susceptible senescent populations and that they promoted chemokine secretion in glioma cells via the senescence‐associated secretory phenotype. By using senolytic agents after radiotherapy to eliminate these senescent cells substantially prolonged survival time in preclinical models. The findings suggest the tumor‐promoting role of senescent astrocytes in the irradiated glioma microenvironment and emphasize the translational relevance of senolytic agents for enhancing the efficacy of radiotherapy in gliomas.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Radiotherapy‐Induced Astrocyte Senescence Promotes an Immunosuppressive Microenvironment in Glioblastoma to Facilitate Tumor Regrowth ; day:11 ; month:02 ; year:2024 ; extent:17
Advanced science ; (11.02.2024) (gesamt 17)
- Creator
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Ji, Jianxiong
Ding, Kaikai
Cheng, Bo
Zhang, Xin
Luo, Tao
Huang, Bin
Yu, Hao
Chen, Yike
Xu, Xiaohui
Lin, Haopu
Zhou, Jiayin
Wang, Tingtin
Jin, Mengmeng
Liu, Aixia
Yan, Danfang
Liu, Fuyi
Wang, Chun
Chen, Jingsen
Yan, Feng
Wang, Lin
Zhang, Jianmin
Yan, Senxiang
Wang, Jian
Li, Xingang
Chen, Gao
- DOI
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10.1002/advs.202304609
- URN
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urn:nbn:de:101:1-2024021214070995498449
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:25 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Ji, Jianxiong
- Ding, Kaikai
- Cheng, Bo
- Zhang, Xin
- Luo, Tao
- Huang, Bin
- Yu, Hao
- Chen, Yike
- Xu, Xiaohui
- Lin, Haopu
- Zhou, Jiayin
- Wang, Tingtin
- Jin, Mengmeng
- Liu, Aixia
- Yan, Danfang
- Liu, Fuyi
- Wang, Chun
- Chen, Jingsen
- Yan, Feng
- Wang, Lin
- Zhang, Jianmin
- Yan, Senxiang
- Wang, Jian
- Li, Xingang
- Chen, Gao
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