Multi‐Tissue Integrated Tissue‐Engineered Trachea Regeneration Based on 3D Printed Bioelastomer Scaffolds
Abstract: Functional segmental trachea reconstruction is a critical concern in thoracic surgery, and tissue‐engineered trachea (TET) holds promise as a potential solution. However, current TET falls short in fully restoring physiological function due to the lack of the intricate multi‐tissue structure found in natural trachea. In this research, a multi‐tissue integrated tissue‐engineered trachea (MI‐TET) is successfully developed by orderly assembling various cells (chondrocytes, fibroblasts and epithelial cells) on 3D‐printed PGS bioelastomer scaffolds. The MI‐TET closely resembles the complex structures of natural trachea and achieves the integrated regeneration of four essential tracheal components: C‐shaped cartilage ring, O‐shaped vascularized fiber ring, axial fiber bundle, and airway epithelium. Overall, the MI‐TET demonstrates highly similar multi‐tissue structures and physiological functions to natural trachea, showing promise for future clinical advancements in functional TETs.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Multi‐Tissue Integrated Tissue‐Engineered Trachea Regeneration Based on 3D Printed Bioelastomer Scaffolds ; day:19 ; month:08 ; year:2024 ; extent:13
Advanced science ; (19.08.2024) (gesamt 13)
- Creator
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Song, Xingqi
Zhang, Peiling
Luo, Bin
Li, Ke
Liu, Yu
Wang, Sinan
Wang, Qianyi
Huang, Jinyi
Qin, Xiaohong
Zhang, Yixin
Zhou, Guangdong
Lei, Dong
- DOI
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10.1002/advs.202405420
- URN
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urn:nbn:de:101:1-2408201427434.183805605146
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:55 AM CEST
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Associated
- Song, Xingqi
- Zhang, Peiling
- Luo, Bin
- Li, Ke
- Liu, Yu
- Wang, Sinan
- Wang, Qianyi
- Huang, Jinyi
- Qin, Xiaohong
- Zhang, Yixin
- Zhou, Guangdong
- Lei, Dong
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