Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells

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Abstract: Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection with E. coli suppresses the LCMV-specific cytotoxic T-lymphocyte (CTL) response and virus elimination in a NK cell- and TLR2/4-dependent manner. Soluble TLR4 ligand LPS also induces NK cell-mediated negative CTL regulation during LCMV infection. NK cells in LPS-treated mice suppress clonal expansion of LCMV-specific CTLs by a NKG2D- or NCR1-independent but perforin-dependent mechanism. These results suggest a TLR4-mediated immunoregulatory role of NK cells during viral-bacterial coinfections

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: Nature communications. - 9, 1 (2018) , 4117, ISSN: 2041-1723

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2019

Creator: Straub, Tobias
Freudenberg, Marina
Schleicher, Ulrike
Bogdan, Christian
Gasteiger, Georg
Pircher, Hanspeter

DOI: 10.1038/s41467-018-06609-z

URN: urn:nbn:de:bsz:25-freidok-1468992

Rights: Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:50 AM CEST

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Time of origin

2019

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