Design, Synthesis and Characterization of Novel Isoxazole Tagged Indole Hybrid Compounds
Abstract: Sixteen new isoxazole tagged indole compounds have been synthesized via copper (I) catalyzed click chemistry of the aryl hydroxamoyl chloride and an indole containing alkyne moiety. The chemical structure of the synthesized compounds has been established using various physicochemical techniques. X-ray single crystal analysis of Ethyl 1-((3-phenylisoxazol-5-yl) methyl)-1H-indole-2-carboxylate (8a) has been analyzed. All compounds were tested for their antibacterial and anticancer activities. The activities for the new compounds were weak against both bacterial strains and the cancer cell lines.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Design, Synthesis and Characterization of Novel Isoxazole Tagged Indole Hybrid Compounds ; volume:18 ; number:1 ; year:2020 ; pages:138-148 ; extent:11
Open chemistry ; 18, Heft 1 (2020), 138-148 (gesamt 11)
- Creator
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Al-Qawasmeh, Raed A.
Al-Nazer, Louy A.
Dawlat-Kari, Sarah A.
Abu-Qatouseh, Luay
Sabri, Salim S.
AlDamen, Murad A.
Sinnokrot, Mutasem
- DOI
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10.1515/chem-2020-0017
- URN
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urn:nbn:de:101:1-2410161635021.413504342804
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:34 AM CEST
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Associated
- Al-Qawasmeh, Raed A.
- Al-Nazer, Louy A.
- Dawlat-Kari, Sarah A.
- Abu-Qatouseh, Luay
- Sabri, Salim S.
- AlDamen, Murad A.
- Sinnokrot, Mutasem
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