Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
Abstract: Epithelial ovarian cancer (EOC) is the leading cause of deaths due to cancer in women. Adipocytes have been suggested to play a key role in the stimulation of EOC growth. However, the mechanisms underlying the adipocyte-induced EOC proliferation remain undefined. Here, we provide the first evidence that adipocytes induce the activation of sphingosine kinase (SphK) 2 in EOC, which represents a novel pathway that mediates the adipocyte-induced EOC growth. SphK2 inhibition in EOC cells led to a remarkable inhibition of the adipocyte-induced cell proliferation. Moreover, the adipocyte-induced SphK2 activation in EOC cells was extracellular signal-regulated protein kinases (ERK) dependent. Furthermore, silencing SphK2 in EOC significantly inhibited the adipocyte-induced expression of phospho-ERK and c-Myc, two crucial players in EOC growth. Collectively, the current study unraveled a previously unrecognized role of SphK2 in the adipocyte-induced growth-promoting action in EOC, suggesting a novel target for EOC treatment.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation ; volume:17 ; number:1 ; year:2022 ; pages:229-238 ; extent:10
Open medicine ; 17, Heft 1 (2022), 229-238 (gesamt 10)
- Urheber
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Dai, Lan
Wang, Chen
Wang, Wenjing
Song, Keqi
Ye, Taiyang
Zhu, Jie
Di, Wen
- DOI
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10.1515/med-2022-0422
- URN
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urn:nbn:de:101:1-2022071515115168819366
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:25 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Dai, Lan
- Wang, Chen
- Wang, Wenjing
- Song, Keqi
- Ye, Taiyang
- Zhu, Jie
- Di, Wen
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