Restless legs syndrome in Parkinson's disease and increased cardiovascular risk

Abstract: Restless legs syndrome (RLS) is a disorder commonly found in patients with Parkinson's disease, with descriptions for both conditions impairing dopaminergic transmission in central nervous system. Previous studies in varied populations indicate an association between the presence of RLS and increased cardiovascular risk and, so far, there are no consistent studies of this association in Parkinson's disease. Objective: To analyze the influence of RLS on cardiovascular risk in patients with Parkinson's disease. Methods: We reviewed the medical records of 202 patients diagnosed with Parkinson's disease and verified the presence of RLS, cardiovascular comorbidities, blood pressure measurements, lipid profiles and Framingham Risk Scores. Results: Statistically significant higher values of total cholesterol were found for the RLS group (mean 216.6 mg/dL), as well as for LDL cholesterol (mean 145 mg/dL). No statistical difference was found among the other factors. Conclusion: Patients with Parkinson's disease and RLS have a higher prevalence of dyslipidemia than patients without RLS, suggesting a correlation between restless legs and hyperlipidemia. It is questioned whether the dopaminergic substrate is the main factor in the genesis of the syndrome, as even with the use of dopaminergic agonists by both groups, it was possible to observe differences between groups. The hypothesis of the real interference of the syndrome treatment as a protective factor for cardiovascular risk was generated.

Angaben zum Objekt

• Weitere Titel: Sndrome das pernas inquietas em doena de Parkinson e aumento do risco cardiovascular
• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Restless legs syndrome in Parkinson's disease and increased cardiovascular risk ; volume:76 ; number:11 ; year:2018 ; pages:731-735 ; Arquivos de neuro-psiquiatria ; 76, Heft 11 (2018), 731-735

Beteiligte, Orts- und Zeitangaben

• Beteiligte Personen und Organisationen: Silva, Maren de Moraes e. ; Lorenzi, Cezar Henrique ; Schneider, Blenda Barreto ; Seidel, Catherine Enk Fischer ; Salom, Isabela ; Gianini, Viktor Cleto Morais ; Pessoa, Renata Ramina ; Mercer, Pilar Bueno Siqueira ; Witt, Maria Carolina Zavagna

Weitere Informationen

• DOI: 10.1590/0004-282X20180114
• URN: urn:nbn:de:101:1-2023100512593812066969
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:45 MESZ