Comparison of Factor VIII Levels After Adrenalin IN Hemophilia a and von Willebrand’s Disease (VWD)

Two-fold or greater increases of Factor VIII procoagulant activity (VIII AHF) have been described following the administration of adrenalin in normal individuals and in some patients with VWD.VIII AHF and Factor VIII-like antigen (VIII AGN) levels were measured pre and one hour post the s. q. injection of adrenalin 0.35 cc. in 4 adult VWD patients and in 10 adult hemophiliacs with VIII AHF levels ranging from 1-29%, normal VIII AGN levels and normal VIII VWF levels as measured by the washed platelet ristocetin assay. Eighteen normal adults served as controls. The four patients with VWD showed two-fold or greater increases of VIII AHF with variable VIII AGN responses. All 10 hemophiliacs showed no change in VIII AHF with significant increases in VIII AGN when analyzed by the paired t-test. The fixed rate of VIII AHF production, release or activation observed in hemophiliacs may help to explain the constancy of VIII AHF levels in individual hemophiliacs and their affected family members. Furthermore, this simple provocative test may be helpful in distinguishing certain VWD patients from those with hemophilia.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Comparison of Factor VIII Levels After Adrenalin IN Hemophilia a and von Willebrand’s Disease (VWD) ; volume:38 ; number:05 ; year:1977 ; Konferenz: XIIth Congress of The World Federation of Hemophilia; 1977-06-22; Philadelphia ; Thrombosis and haemostasis ; 38, Heft 05 (1977)

Contributors, Places and Time

• Contributor: Eyster, M.E. ; Ballard, J.O. ; Prager, D.

Further information

• DOI: 10.1055/s-0039-1682513
• URN: urn:nbn:de:101:1-2412190837180.817330595495
• Rights: Open Access unbekannt; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:33 AM CEST